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Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition

Ward, Heather A.; Wark, Petra A.; Muller, David C; Steffen, Annika; Johansson, Mattias; Norat, Teresa; Gunter, Marc J.; Overvad, Kim; Dahm, Christina and Halkjær, Jytte, et al. (2017) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 26(6). p.895-904
Abstract

BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.

METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.

RESULTS: Among men, a BMI... (More)

BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.

METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.

RESULTS: Among men, a BMI < 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65).

CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated.

IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.

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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
volume
26
issue
6
pages
895 - 904
publisher
American Association for Cancer Research
external identifiers
  • scopus:85020171454
  • wos:000402765600011
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-16-0886
language
English
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yes
id
f5f74b15-c7c9-422b-a6a2-302ce7ad1bb1
date added to LUP
2017-02-13 16:45:34
date last changed
2018-01-07 11:49:31
@article{f5f74b15-c7c9-422b-a6a2-302ce7ad1bb1,
  abstract     = {<p>BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.</p><p>METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: &lt; 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: &gt; 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.</p><p>RESULTS: Among men, a BMI &lt; 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65).</p><p>CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated.</p><p>IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.</p>},
  author       = {Ward, Heather A. and Wark, Petra A. and Muller, David C and Steffen, Annika and Johansson, Mattias and Norat, Teresa and Gunter, Marc J. and Overvad, Kim and Dahm, Christina and Halkjær, Jytte and Tjønneland, Anne and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and Mesrine, Sylvie and Brennan, Paul and Freisling, Heinz and Li, Kuanrong and Kaaks, Rudolf and Trichopoulou, Antonia and Lagiou, Pagona and Panico, Salvatore and Grioni, Sara and Tumino, Rosario and Vineis, Paolo and Palli, Domenico and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and Weiderpass, Elisabete and Agudo, Antonio and Ramon Quiros, Jose and Larrañaga, Nerea and Ardanaz, Eva and Huerta, José María and Sánchez, María-José and Laurell, Goran and Johansson, Ingegerd and Westin, Ulla and Wallström, Peter and Bradbury, Kathryn E and Wareham, Nicholas J and Khaw, Kay Tee and Pearson, Clare and Boeing, Heiner and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  month        = {02},
  number       = {6},
  pages        = {895--904},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  title        = {Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-16-0886},
  volume       = {26},
  year         = {2017},
}