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Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders : A Meta-analysis

Ulugut, Hulya ; Trieu, Calvin ; Groot, Colin ; van ’t Hooft, Jochum J. ; Tijms, Betty M. ; Scheltens, Philip ; Ossenkoppele, Rik LU ; Barkhof, Frederik ; van den Heuvel, Odile A. and Pijnenburg, Yolande A.L. (2023) In Biological Psychiatry 93(9). p.820-828
Abstract

Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and... (More)

Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autism spectrum disorder, Behavior, Bipolar disorder, Dementia, Frontotemporal dementia, Schizophrenia
in
Biological Psychiatry
volume
93
issue
9
pages
820 - 828
publisher
Elsevier
external identifiers
  • pmid:35965106
  • scopus:85136749563
ISSN
0006-3223
DOI
10.1016/j.biopsych.2022.05.028
language
English
LU publication?
yes
id
f5fee8ec-f5bd-44c2-8b73-77c080b34d15
date added to LUP
2022-10-24 13:48:22
date last changed
2024-04-18 03:47:13
@article{f5fee8ec-f5bd-44c2-8b73-77c080b34d15,
  abstract     = {{<p>Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.</p>}},
  author       = {{Ulugut, Hulya and Trieu, Calvin and Groot, Colin and van ’t Hooft, Jochum J. and Tijms, Betty M. and Scheltens, Philip and Ossenkoppele, Rik and Barkhof, Frederik and van den Heuvel, Odile A. and Pijnenburg, Yolande A.L.}},
  issn         = {{0006-3223}},
  keywords     = {{Autism spectrum disorder; Behavior; Bipolar disorder; Dementia; Frontotemporal dementia; Schizophrenia}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{820--828}},
  publisher    = {{Elsevier}},
  series       = {{Biological Psychiatry}},
  title        = {{Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders : A Meta-analysis}},
  url          = {{http://dx.doi.org/10.1016/j.biopsych.2022.05.028}},
  doi          = {{10.1016/j.biopsych.2022.05.028}},
  volume       = {{93}},
  year         = {{2023}},
}