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Chronic inflammation in the etiology of disease across the life span

Furman, David ; Campisi, Judith ; Verdin, Eric ; Carrera-Bastos, Pedro LU ; Targ, Sasha ; Franceschi, Claudio ; Ferrucci, Luigi ; Gilroy, Derek W. ; Fasano, Alessio and Miller, Gary W. , et al. (2019) In Nature Medicine 25(12). p.1822-1832
Abstract

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet,... (More)

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
25
issue
12
pages
1822 - 1832
publisher
Nature Publishing Group
external identifiers
  • pmid:31806905
  • scopus:85076175435
ISSN
1078-8956
DOI
10.1038/s41591-019-0675-0
language
English
LU publication?
yes
id
f6280925-1770-4625-b4e3-86bb13ee24fc
date added to LUP
2020-11-03 16:52:34
date last changed
2024-04-03 15:30:42
@article{f6280925-1770-4625-b4e3-86bb13ee24fc,
  abstract     = {{<p>Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.</p>}},
  author       = {{Furman, David and Campisi, Judith and Verdin, Eric and Carrera-Bastos, Pedro and Targ, Sasha and Franceschi, Claudio and Ferrucci, Luigi and Gilroy, Derek W. and Fasano, Alessio and Miller, Gary W. and Miller, Andrew H. and Mantovani, Alberto and Weyand, Cornelia M. and Barzilai, Nir and Goronzy, Jorg J. and Rando, Thomas A. and Effros, Rita B. and Lucia, Alejandro and Kleinstreuer, Nicole and Slavich, George M.}},
  issn         = {{1078-8956}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  pages        = {{1822--1832}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{Chronic inflammation in the etiology of disease across the life span}},
  url          = {{http://dx.doi.org/10.1038/s41591-019-0675-0}},
  doi          = {{10.1038/s41591-019-0675-0}},
  volume       = {{25}},
  year         = {{2019}},
}