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Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study

Yarnall, Alison J; Breen, David P; Duncan, Gordon W; Khoo, Tien K; Coleman, Shirley Y; Firbank, Michael J; Nombela, Cristina; Winder-Rhodes, Sophie; Evans, Jonathan R and Rowe, James B, et al. (2014) In Neurology 82(4). p.16-308
Abstract

OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory... (More)

OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.

CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

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@article{f6313df0-36f6-407b-be06-2cbcd1a5b70c,
  abstract     = {<p>OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.</p><p>METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.</p><p>RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.</p><p>CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.</p>},
  author       = {Yarnall, Alison J and Breen, David P and Duncan, Gordon W and Khoo, Tien K and Coleman, Shirley Y and Firbank, Michael J and Nombela, Cristina and Winder-Rhodes, Sophie and Evans, Jonathan R and Rowe, James B and Mollenhauer, Brit and Kruse, Niels and Hudson, Gavin and Chinnery, Patrick F and O'Brien, John T and Robbins, Trevor W and Wesnes, Keith and Brooks, David J and Barker, Roger A and Burn, David J and , },
  issn         = {1526-632X},
  keyword      = {Aged,Aged, 80 and over,Amyloid beta-Peptides,Case-Control Studies,Female,Humans,Intermediate Filament Proteins,Male,Middle Aged,Mild Cognitive Impairment,Neuropsychological Tests,Parkinson Disease,Peptide Fragments,Retrospective Studies,Severity of Illness Index,tau Proteins,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {16--308},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study},
  url          = {http://dx.doi.org/10.1212/WNL.0000000000000066},
  volume       = {82},
  year         = {2014},
}