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Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study

Yarnall, Alison J ; Breen, David P ; Duncan, Gordon W ; Khoo, Tien K ; Coleman, Shirley Y ; Firbank, Michael J ; Nombela, Cristina ; Winder-Rhodes, Sophie ; Evans, Jonathan R and Rowe, James B , et al. (2014) In Neurology 82(4). p.16-308
Abstract

OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory... (More)

OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.

CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

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Please use this url to cite or link to this publication:
@article{f6313df0-36f6-407b-be06-2cbcd1a5b70c,
  abstract     = {{<p>OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.</p><p>METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.</p><p>RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.</p><p>CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.</p>}},
  author       = {{Yarnall, Alison J and Breen, David P and Duncan, Gordon W and Khoo, Tien K and Coleman, Shirley Y and Firbank, Michael J and Nombela, Cristina and Winder-Rhodes, Sophie and Evans, Jonathan R and Rowe, James B and Mollenhauer, Brit and Kruse, Niels and Hudson, Gavin and Chinnery, Patrick F and O'Brien, John T and Robbins, Trevor W and Wesnes, Keith and Brooks, David J and Barker, Roger A and Burn, David J}},
  issn         = {{1526-632X}},
  keywords     = {{Aged; Aged, 80 and over; Amyloid beta-Peptides; Case-Control Studies; Female; Humans; Intermediate Filament Proteins; Male; Middle Aged; Mild Cognitive Impairment; Neuropsychological Tests; Parkinson Disease; Peptide Fragments; Retrospective Studies; Severity of Illness Index; tau Proteins; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{16--308}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Neurology}},
  title        = {{Characterizing mild cognitive impairment in incident Parkinson disease : the ICICLE-PD study}},
  url          = {{http://dx.doi.org/10.1212/WNL.0000000000000066}},
  doi          = {{10.1212/WNL.0000000000000066}},
  volume       = {{82}},
  year         = {{2014}},
}