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Non-Lamellar lipid assembly at interfaces : Controlling layer structure by responsive nanogel particles

Dabkowska, Aleksandra P. LU ; Valldeperas Badell, Maria LU ; Hirst, Christopher LU ; Montis, Costanza; Pálsson, Gunnar K.; Wang, Meina LU ; Nöjd, Sofi LU ; Gentile, Luigi LU ; Barauskas, Justas LU and Steinke, Nina Juliane, et al. (2017) In Interface Focus 7(4).
Abstract

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid... (More)

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.

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publication status
published
subject
keywords
Cubic bicontinuous phases, Lipid non-lamellar liquid crystalline, Microgel, Nanogel, Neutron reflectivity, Responsive lipid layers
in
Interface Focus
volume
7
issue
4
publisher
Royal Society Publishing
external identifiers
  • scopus:85020873968
  • wos:000403686000012
ISSN
2042-8898
DOI
10.1098/rsfs.2016.0150
language
English
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yes
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f6febadd-b1f6-4743-b8fb-470e678d982b
date added to LUP
2017-07-05 08:19:18
date last changed
2017-09-18 11:37:47
@article{f6febadd-b1f6-4743-b8fb-470e678d982b,
  abstract     = {<p>Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.</p>},
  author       = {Dabkowska, Aleksandra P. and Valldeperas Badell, Maria and Hirst, Christopher and Montis, Costanza and Pálsson, Gunnar K. and Wang, Meina and Nöjd, Sofi and Gentile, Luigi and Barauskas, Justas and Steinke, Nina Juliane and Schroeder-Turk, Gerd E. and George, Sebastian and Skoda, Maximilian W A and Nylander, Tommy},
  issn         = {2042-8898},
  keyword      = {Cubic bicontinuous phases,Lipid non-lamellar liquid crystalline,Microgel,Nanogel,Neutron reflectivity,Responsive lipid layers},
  language     = {eng},
  number       = {4},
  publisher    = {Royal Society Publishing},
  series       = {Interface Focus},
  title        = {Non-Lamellar lipid assembly at interfaces : Controlling layer structure by responsive nanogel particles},
  url          = {http://dx.doi.org/10.1098/rsfs.2016.0150},
  volume       = {7},
  year         = {2017},
}