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Panel 6 : Vaccines

Pettigrew, Melinda M; Alderson, Mark R.; Bakaletz, Lauren O.; Barenkamp, Stephen J.; Hakansson, Anders P. LU ; Mason, Kevin M.; Nokso-Koivisto, Johanna; Patel, Janak A.; Pelton, Stephen I. and Murphy, Timothy F. (2017) In Otolaryngology - Head and Neck Surgery 156(4_suppl). p.76-87
Abstract

Objective: To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources: PubMed database of the National Library of Science. Review Methods: We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise. Conclusions: Pneumococcal conjugate vaccines (PCVs) are somewhat effective for the prevention of pneumococcal OM, recurrent OM, OM visits, and tympanostomy tube insertions. Widespread use of PCVs has... (More)

Objective: To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources: PubMed database of the National Library of Science. Review Methods: We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise. Conclusions: Pneumococcal conjugate vaccines (PCVs) are somewhat effective for the prevention of pneumococcal OM, recurrent OM, OM visits, and tympanostomy tube insertions. Widespread use of PCVs has been associated with shifts in pneumococcal serotypes and bacterial pathogens associated with OM, diminishing PCV effectiveness against AOM. The 10-valent pneumococcal vaccine containing Haemophilus influenzae protein D (PHiD-CV) is effective for pneumococcal OM, but results from studies describing the potential impact on OM due to H influenzae have been inconsistent. Progress in vaccine development for H influenzae, Moraxella catarrhalis, and OM-associated respiratory viruses has been limited. Additional research is needed to extend vaccine protection to additional pneumococcal serotypes and other otopathogens. There are likely to be licensure challenges for protein-based vaccines, and data on correlates of protection for OM vaccine antigens are urgently needed. Implications for Practice: OM continues to be a significant health care burden globally. Prevention is preferable to treatment, and vaccine development remains an important goal. As a polymicrobial disease, OM poses significant but not insurmountable challenges for vaccine development.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
children, Haemophilus influenzae, Moraxella catarrhalis, otitis media, Streptococcus pneumoniae, vaccines
in
Otolaryngology - Head and Neck Surgery
volume
156
issue
4_suppl
pages
76 - 87
publisher
Mosby
external identifiers
  • scopus:85018964771
  • wos:000402853500006
ISSN
0194-5998
DOI
10.1177/0194599816632178
language
English
LU publication?
yes
id
f705ae4e-533a-4009-97af-91cb8a4ddc5b
date added to LUP
2017-06-14 09:48:30
date last changed
2018-05-29 10:20:56
@article{f705ae4e-533a-4009-97af-91cb8a4ddc5b,
  abstract     = {<p>Objective: To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources: PubMed database of the National Library of Science. Review Methods: We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise. Conclusions: Pneumococcal conjugate vaccines (PCVs) are somewhat effective for the prevention of pneumococcal OM, recurrent OM, OM visits, and tympanostomy tube insertions. Widespread use of PCVs has been associated with shifts in pneumococcal serotypes and bacterial pathogens associated with OM, diminishing PCV effectiveness against AOM. The 10-valent pneumococcal vaccine containing Haemophilus influenzae protein D (PHiD-CV) is effective for pneumococcal OM, but results from studies describing the potential impact on OM due to H influenzae have been inconsistent. Progress in vaccine development for H influenzae, Moraxella catarrhalis, and OM-associated respiratory viruses has been limited. Additional research is needed to extend vaccine protection to additional pneumococcal serotypes and other otopathogens. There are likely to be licensure challenges for protein-based vaccines, and data on correlates of protection for OM vaccine antigens are urgently needed. Implications for Practice: OM continues to be a significant health care burden globally. Prevention is preferable to treatment, and vaccine development remains an important goal. As a polymicrobial disease, OM poses significant but not insurmountable challenges for vaccine development.</p>},
  author       = {Pettigrew, Melinda M and Alderson, Mark R. and Bakaletz, Lauren O. and Barenkamp, Stephen J. and Hakansson, Anders P. and Mason, Kevin M. and Nokso-Koivisto, Johanna and Patel, Janak A. and Pelton, Stephen I. and Murphy, Timothy F.},
  issn         = {0194-5998},
  keyword      = {children,Haemophilus influenzae,Moraxella catarrhalis,otitis media,Streptococcus pneumoniae,vaccines},
  language     = {eng},
  month        = {04},
  number       = {4_suppl},
  pages        = {76--87},
  publisher    = {Mosby},
  series       = {Otolaryngology - Head and Neck Surgery},
  title        = {Panel 6 : Vaccines},
  url          = {http://dx.doi.org/10.1177/0194599816632178},
  volume       = {156},
  year         = {2017},
}