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Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0

Isaksson, Marléne LU ; Ale, Iris ; Andersen, Klaus E. ; Goh, Chee Leok ; Goossens, An ; Jerajani, Hemangi ; Matsunaga, Kayoko ; McFadden, John and Bruze, Magnus LU (2019) In Dermatitis : contact, atopic, occupational, drug 30(6). p.342-346
Abstract

BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46... (More)

BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq. CONCLUSIONS: The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis : contact, atopic, occupational, drug
volume
30
issue
6
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85075056791
  • pmid:31730552
ISSN
1710-3568
DOI
10.1097/DER.0000000000000510
language
English
LU publication?
yes
id
f7364e99-d238-4e37-ad96-5b7b4f644c93
date added to LUP
2019-11-29 14:28:20
date last changed
2022-05-23 19:46:03
@article{f7364e99-d238-4e37-ad96-5b7b4f644c93,
  abstract     = {{<p>BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P &lt; 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq. CONCLUSIONS: The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.</p>}},
  author       = {{Isaksson, Marléne and Ale, Iris and Andersen, Klaus E. and Goh, Chee Leok and Goossens, An and Jerajani, Hemangi and Matsunaga, Kayoko and McFadden, John and Bruze, Magnus}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{342--346}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis : contact, atopic, occupational, drug}},
  title        = {{Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000510}},
  doi          = {{10.1097/DER.0000000000000510}},
  volume       = {{30}},
  year         = {{2019}},
}