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An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study

Ulven, Stine M. ; Holven, Kirsten B. ; Rundblad, Amanda ; Myhrstad, Mari C.W. ; Leder, Lena ; Dahlman, Ingrid ; de Mello, Vanessa D. ; Schwab, Ursula ; Carlberg, Carsten and Pihlajamäki, Jussi , et al. (2019) In Nutrients 11(12).
Abstract

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were... (More)

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gene expression, Inflammation, Metabolic syndrome, Peripheral blood mononuclear cells, Randomized controlled dietary intervention
in
Nutrients
volume
11
issue
12
article number
2932
publisher
MDPI AG
external identifiers
  • scopus:85076023786
  • pmid:31816875
ISSN
2072-6643
DOI
10.3390/nu11122932
language
English
LU publication?
yes
id
f73ec833-4917-485c-abd6-2d59f51c70a1
date added to LUP
2020-01-03 15:19:24
date last changed
2024-06-12 07:10:09
@article{f73ec833-4917-485c-abd6-2d59f51c70a1,
  abstract     = {{<p>A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.</p>}},
  author       = {{Ulven, Stine M. and Holven, Kirsten B. and Rundblad, Amanda and Myhrstad, Mari C.W. and Leder, Lena and Dahlman, Ingrid and de Mello, Vanessa D. and Schwab, Ursula and Carlberg, Carsten and Pihlajamäki, Jussi and Hermansen, Kjeld and Dragsted, Lars O. and Gunnarsdottir, Ingibjörg and Cloetens, Lieselotte and Åkesson, Björn and Rosqvist, Fredrik and Hukkanen, Janne and Herzig, Karl Heinz and Savolainen, Markku J. and Risérus, Ulf and Thorsdottir, Inga and Poutanen, Kaisa S. and Arner, Peter and Uusitupa, Matti and Kolehmainen, Marjukka}},
  issn         = {{2072-6643}},
  keywords     = {{Gene expression; Inflammation; Metabolic syndrome; Peripheral blood mononuclear cells; Randomized controlled dietary intervention}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study}},
  url          = {{http://dx.doi.org/10.3390/nu11122932}},
  doi          = {{10.3390/nu11122932}},
  volume       = {{11}},
  year         = {{2019}},
}