Advanced

Treating Parkinson's disease in the 21st century : can stem cell transplantation compete?

Buttery, Philip C and Barker, Roger A LU (2014) In Journal of Comparative Neurology 522(12). p.16-2802
Abstract

The characteristic and selective degeneration of a unique population of cells-the nigrostriatal dopamine (DA) neurons-that occurs in Parkinson's disease (PD) has made the condition an iconic target for cell replacement therapies. Indeed, transplantation of fetal ventral mesencephalic cells into the DA-deficient striatum was first trialled nearly 30 years ago, at a time when other treatments for the disease were less well developed. Over recent decades standard treatments for PD have advanced, and newer biological therapies are now emerging. In the 21st century, stem cell technology will have to compete alongside other sophisticated treatments, including deep brain stimulation and gene therapies. In this review we examine how stem... (More)

The characteristic and selective degeneration of a unique population of cells-the nigrostriatal dopamine (DA) neurons-that occurs in Parkinson's disease (PD) has made the condition an iconic target for cell replacement therapies. Indeed, transplantation of fetal ventral mesencephalic cells into the DA-deficient striatum was first trialled nearly 30 years ago, at a time when other treatments for the disease were less well developed. Over recent decades standard treatments for PD have advanced, and newer biological therapies are now emerging. In the 21st century, stem cell technology will have to compete alongside other sophisticated treatments, including deep brain stimulation and gene therapies. In this review we examine how stem cell-based transplantation therapies compare with these novel and emerging treatments in the management of this common condition. J. Comp. Neurol. 522:2802-2816, 2014. © 2014 Wiley Periodicals, Inc.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
History, 21st Century, Humans, Parkinson Disease, Stem Cell Transplantation, Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Journal of Comparative Neurology
volume
522
issue
12
pages
15 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84911994237
ISSN
1096-9861
DOI
10.1002/cne.23577
language
English
LU publication?
no
id
f745ce82-ca19-4ee5-97ff-1517483fca50
date added to LUP
2016-11-24 15:11:01
date last changed
2017-11-19 04:35:12
@article{f745ce82-ca19-4ee5-97ff-1517483fca50,
  abstract     = {<p>The characteristic and selective degeneration of a unique population of cells-the nigrostriatal dopamine (DA) neurons-that occurs in Parkinson's disease (PD) has made the condition an iconic target for cell replacement therapies. Indeed, transplantation of fetal ventral mesencephalic cells into the DA-deficient striatum was first trialled nearly 30 years ago, at a time when other treatments for the disease were less well developed. Over recent decades standard treatments for PD have advanced, and newer biological therapies are now emerging. In the 21st century, stem cell technology will have to compete alongside other sophisticated treatments, including deep brain stimulation and gene therapies. In this review we examine how stem cell-based transplantation therapies compare with these novel and emerging treatments in the management of this common condition. J. Comp. Neurol. 522:2802-2816, 2014. © 2014 Wiley Periodicals, Inc.</p>},
  author       = {Buttery, Philip C and Barker, Roger A},
  issn         = {1096-9861},
  keyword      = {History, 21st Century,Humans,Parkinson Disease,Stem Cell Transplantation,Historical Article,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  month        = {08},
  number       = {12},
  pages        = {16--2802},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Comparative Neurology},
  title        = {Treating Parkinson's disease in the 21st century : can stem cell transplantation compete?},
  url          = {http://dx.doi.org/10.1002/cne.23577},
  volume       = {522},
  year         = {2014},
}