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Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder

Wlad, Magdalena ; Frick, Andreas ; Engman, Jonas ; Hjorth, Olof ; Hoppe, Johanna M. ; Faria, Vanda ; Wahlstedt, Kurt ; Björkstrand, Johannes LU ; Månsson, Kristoffer NT and Hultberg, Sara , et al. (2023) In Behavioural Brain Research 442.
Abstract

Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Methods: Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels. Results: The MSIT activated the dACC as expected but with no differences in... (More)

Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Methods: Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels. Results: The MSIT activated the dACC as expected but with no differences in task performance or neural reactivity between SAD patients and controls. There were no significant correlations between dACC activity and social or trait anxiety symptom severity. In patients, there was a significant negative correlation between dACC activity and depressive symptoms. Conclusions: In absence of affective challenge, we found no disorder-related cognitive profile in SAD patients since neither MSIT task performance nor dACC neural activity deviated in patients relative to controls.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anterior cingulate cortex, Functional magnetic resonance imaging, Social anxiety disorder
in
Behavioural Brain Research
volume
442
article number
114304
publisher
Elsevier
external identifiers
  • scopus:85146648393
  • pmid:36681164
ISSN
0166-4328
DOI
10.1016/j.bbr.2023.114304
language
English
LU publication?
yes
id
f75f158d-690d-4db0-9bb1-0cc40608ff98
date added to LUP
2023-02-10 14:24:35
date last changed
2024-06-13 05:00:31
@article{f75f158d-690d-4db0-9bb1-0cc40608ff98,
  abstract     = {{<p>Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Methods: Here, we used fMRI to compare dACC activity and test performance during MSIT in 69 SAD patients and 38 healthy controls. In addition to patient-control comparisons, we examined whether neural activity in the dACC correlated with social anxiety, trait anxiety or depression levels. Results: The MSIT activated the dACC as expected but with no differences in task performance or neural reactivity between SAD patients and controls. There were no significant correlations between dACC activity and social or trait anxiety symptom severity. In patients, there was a significant negative correlation between dACC activity and depressive symptoms. Conclusions: In absence of affective challenge, we found no disorder-related cognitive profile in SAD patients since neither MSIT task performance nor dACC neural activity deviated in patients relative to controls.</p>}},
  author       = {{Wlad, Magdalena and Frick, Andreas and Engman, Jonas and Hjorth, Olof and Hoppe, Johanna M. and Faria, Vanda and Wahlstedt, Kurt and Björkstrand, Johannes and Månsson, Kristoffer NT and Hultberg, Sara and Alaie, Iman and Rosén, Jörgen and Fredrikson, Mats and Furmark, Tomas and Gingnell, Malin}},
  issn         = {{0166-4328}},
  keywords     = {{Anterior cingulate cortex; Functional magnetic resonance imaging; Social anxiety disorder}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Behavioural Brain Research}},
  title        = {{Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder}},
  url          = {{http://dx.doi.org/10.1016/j.bbr.2023.114304}},
  doi          = {{10.1016/j.bbr.2023.114304}},
  volume       = {{442}},
  year         = {{2023}},
}