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Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease

Collins, Lucy M; Begeti, Faye; Panin, Francesca; Lazar, Alpar S; Cruickshank, Travis; Ziman, Mel; Mason, Sarah L and Barker, Roger A LU (2015) In PLoS Currents 7.
Abstract

BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.

METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.

RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.

CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a... (More)

BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.

METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.

RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.

CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article
in
PLoS Currents
volume
7
publisher
Public Library of Science
external identifiers
  • scopus:84958559094
ISSN
2157-3999
DOI
10.1371/currents.hd.ded251617ae62a1364506b0521bd3761
language
English
LU publication?
no
id
f79ae46a-ade3-4f2b-a276-20ad3f6b968c
date added to LUP
2016-11-23 13:26:58
date last changed
2017-01-01 08:40:32
@article{f79ae46a-ade3-4f2b-a276-20ad3f6b968c,
  abstract     = {<p>BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.</p><p>METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.</p><p>RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.</p><p>CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.</p>},
  author       = {Collins, Lucy M and Begeti, Faye and Panin, Francesca and Lazar, Alpar S and Cruickshank, Travis and Ziman, Mel and Mason, Sarah L and Barker, Roger A},
  issn         = {2157-3999},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {09},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease},
  url          = {http://dx.doi.org/10.1371/currents.hd.ded251617ae62a1364506b0521bd3761},
  volume       = {7},
  year         = {2015},
}