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Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3

Sabbah, Muhammad ; Veien, Karsten ; Niemela, Matti ; Freeman, Phillip ; Linder, Rickard ; Ioanes, Dan ; Terkelsen, Christian Juhl ; Kajander, Olli A. ; Koul, Sasha LU and Savontaus, Mikko , et al. (2023) In American Heart Journal 255. p.39-51
Abstract

Background: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes. Study design: The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to... (More)

Background: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes. Study design: The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to TAVI. Patients are eligible for the study in the presence of at least 1 significant PCI-eligible coronary stenosis. A significant stenosis is defined as either FFR ≤0.80 and/or diameter stenosis >90%. The primary end point is a composite of first occurring all-cause mortality, myocardial infarction, or urgent revascularization (PCI or coronary artery bypass graft performed during unplanned hospital admission) until the last included patient have been followed for 1 year after the TAVI. NOTION-3 is a multicenter, multinational randomized trial aiming at comparing FFR-guided revascularization vs medical treatment of CAD in patients with severe AS planned for TAVI.

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type
Contribution to journal
publication status
published
subject
in
American Heart Journal
volume
255
pages
13 pages
publisher
Mosby-Elsevier
external identifiers
  • pmid:36220354
  • scopus:85140977677
ISSN
0002-8703
DOI
10.1016/j.ahj.2022.10.009
language
English
LU publication?
yes
id
f7af0fe4-390b-4484-999f-7026d1011641
date added to LUP
2023-01-24 09:09:11
date last changed
2024-04-18 05:18:19
@article{f7af0fe4-390b-4484-999f-7026d1011641,
  abstract     = {{<p>Background: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes. Study design: The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to TAVI. Patients are eligible for the study in the presence of at least 1 significant PCI-eligible coronary stenosis. A significant stenosis is defined as either FFR ≤0.80 and/or diameter stenosis &gt;90%. The primary end point is a composite of first occurring all-cause mortality, myocardial infarction, or urgent revascularization (PCI or coronary artery bypass graft performed during unplanned hospital admission) until the last included patient have been followed for 1 year after the TAVI. NOTION-3 is a multicenter, multinational randomized trial aiming at comparing FFR-guided revascularization vs medical treatment of CAD in patients with severe AS planned for TAVI.</p>}},
  author       = {{Sabbah, Muhammad and Veien, Karsten and Niemela, Matti and Freeman, Phillip and Linder, Rickard and Ioanes, Dan and Terkelsen, Christian Juhl and Kajander, Olli A. and Koul, Sasha and Savontaus, Mikko and Karjalainen, Pasi and Erglis, Andrejs and Minkkinen, Mikko and Jørgensen, Troels and Sondergaard, Lars and De Backer, Ole and Engstrøm, Thomas and Lønborg, Jacob}},
  issn         = {{0002-8703}},
  language     = {{eng}},
  pages        = {{39--51}},
  publisher    = {{Mosby-Elsevier}},
  series       = {{American Heart Journal}},
  title        = {{Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3}},
  url          = {{http://dx.doi.org/10.1016/j.ahj.2022.10.009}},
  doi          = {{10.1016/j.ahj.2022.10.009}},
  volume       = {{255}},
  year         = {{2023}},
}