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The effects of trifluoperazine on fast and slow axonal transport in the rabbit vagus nerve

Ekström, Per LU ; Kanje, Martin LU and McLean, W. Graham (1987) In Journal of Neurobiology 18(3). p.283-293
Abstract

The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main... (More)

The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main target of the drug.

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type
Contribution to journal
publication status
published
subject
in
Journal of Neurobiology
volume
18
issue
3
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:2439654
  • scopus:0023218132
ISSN
0022-3034
DOI
10.1002/neu.480180304
language
English
LU publication?
yes
id
f7c3a9f8-d067-4bac-9625-20134a882bdc
date added to LUP
2016-12-07 14:29:25
date last changed
2024-01-04 18:19:14
@article{f7c3a9f8-d067-4bac-9625-20134a882bdc,
  abstract     = {{<p>The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of <sup>3</sup>H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main target of the drug.</p>}},
  author       = {{Ekström, Per and Kanje, Martin and McLean, W. Graham}},
  issn         = {{0022-3034}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{283--293}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Neurobiology}},
  title        = {{The effects of trifluoperazine on fast and slow axonal transport in the rabbit vagus nerve}},
  url          = {{http://dx.doi.org/10.1002/neu.480180304}},
  doi          = {{10.1002/neu.480180304}},
  volume       = {{18}},
  year         = {{1987}},
}