Dynamic glucose enhanced chemical exchange saturation transfer MRI : Optimization of methodology and characterization of cerebral transport kinetics
(2023)- Abstract
- Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. However, as with most novel techniques, DGE MRI is associated with technical challenges, including small contrast enhancement compared to conventional techniques, sensitivity to motion and long scan durations. Therefore, DGE MRI is not yet ready for clinical implementation, and further evaluation and methodological development are required.... (More)
- Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. However, as with most novel techniques, DGE MRI is associated with technical challenges, including small contrast enhancement compared to conventional techniques, sensitivity to motion and long scan durations. Therefore, DGE MRI is not yet ready for clinical implementation, and further evaluation and methodological development are required.
The focus of the work presented in this thesis has been on the optimization and development of DGE MRI in humans. We first implemented the DGE MRI technique at 7 T for evaluation in healthy volunteers, and subsequently optimized and applied the DGE imaging protocol at 3 T. We demonstrated that it is possible to measure arterial input functions using DGE MRI data, and that the arterial DGE MRI signal is correlated to the venous blood glucose level. Our experiments also showed that the glucose infusion duration should preferably be prolonged to minimize the sensory side effects of the injection. We also evaluated and compared DGE MRI tissue response curves in healthy tissue and in brain tumours and confirmed that DGE MRI enables differentiation of tumour from normal tissue, but that motion-related artefacts may complicate the interpretation. We developed a post-processing method for DGE MRI based on visualization of tissue response curve types with different characteristic temporal enhancement patterns. Finally, we developed a model for kinetic analysis of DGE MRI, accounting for the different signal origin and uptake kinetics of normal D-glucose.
In summary, DGE MRI has potential for tumour detection in humans and can provide information on glucose delivery, transport, and metabolism. However, further optimization of imaging and post-processing techniques is necessary, especially at lower field strengths. (Less) - Abstract (Swedish)
- Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. However, as with most novel techniques, DGE MRI is associated with technical challenges, including small contrast enhancement compared to conventional techniques, sensitivity to motion and long scan durations. Therefore, DGE MRI is not yet ready for clinical implementation, and further evaluation and methodological development are required.... (More)
- Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. However, as with most novel techniques, DGE MRI is associated with technical challenges, including small contrast enhancement compared to conventional techniques, sensitivity to motion and long scan durations. Therefore, DGE MRI is not yet ready for clinical implementation, and further evaluation and methodological development are required.
The focus of the work presented in this thesis has been on the optimization and development of DGE MRI in humans. We first implemented the DGE MRI technique at 7 T for evaluation in healthy volunteers, and subsequently optimized and applied the DGE imaging protocol at 3 T. We demonstrated that it is possible to measure arterial input functions using DGE MRI data, and that the arterial DGE MRI signal is correlated to the venous blood glucose level. Our experiments also showed that the glucose infusion duration should preferably be prolonged to minimize the sensory side effects of the injection. We also evaluated and compared DGE MRI tissue response curves in healthy tissue and in brain tumours and confirmed that DGE MRI enables differentiation of tumour from normal tissue, but that motion-related artefacts may complicate the interpretation. We developed a post-processing method for DGE MRI based on visualization of tissue response curve types with different characteristic temporal enhancement patterns. Finally, we developed a model for kinetic analysis of DGE MRI, accounting for the different signal origin and uptake kinetics of normal D-glucose.
In summary, DGE MRI has potential for tumour detection in humans and can provide information on glucose delivery, transport, and metabolism. However, further optimization of imaging and post-processing techniques is necessary, especially at lower field strengths. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f7e2e1d1-08bf-4a3e-849a-7924c3071a3a
- author
- Seidemo, Anina LU
- supervisor
-
- Linda Knutsson LU
- Ronnie Wirestam LU
- Gunther Helms LU
- opponent
-
- Assistant professor Paech, Daniel, Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- organization
- publishing date
- 2023-04-04
- type
- Thesis
- publication status
- published
- subject
- keywords
- Chemical exchange saturation transfer (CEST), Dynamic glucose enhanced (DGE) MRI, GlucoCEST, MRI, D-glucose, Fysicumarkivet A:2023:Seidemo
- pages
- 170 pages
- publisher
- Lund University
- defense location
- Föreläsningssal 3, Centralblocket, Entrégatan 7, Skånes Universitetssjukhus, Lund.
- defense date
- 2023-04-28 09:00:00
- ISBN
- 978-91-8039-554-0
- 978-91-8039-555-7
- project
- Dynamic glucose enhanced chemical exchange saturation transfer MRI: Optimization of methodology and characterization of cerebral transport kinetics
- language
- English
- LU publication?
- yes
- id
- f7e2e1d1-08bf-4a3e-849a-7924c3071a3a
- date added to LUP
- 2023-04-03 12:56:15
- date last changed
- 2023-05-31 10:04:14
@phdthesis{f7e2e1d1-08bf-4a3e-849a-7924c3071a3a,
abstract = {{Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. However, as with most novel techniques, DGE MRI is associated with technical challenges, including small contrast enhancement compared to conventional techniques, sensitivity to motion and long scan durations. Therefore, DGE MRI is not yet ready for clinical implementation, and further evaluation and methodological development are required. <br/><br/>The focus of the work presented in this thesis has been on the optimization and development of DGE MRI in humans. We first implemented the DGE MRI technique at 7 T for evaluation in healthy volunteers, and subsequently optimized and applied the DGE imaging protocol at 3 T. We demonstrated that it is possible to measure arterial input functions using DGE MRI data, and that the arterial DGE MRI signal is correlated to the venous blood glucose level. Our experiments also showed that the glucose infusion duration should preferably be prolonged to minimize the sensory side effects of the injection. We also evaluated and compared DGE MRI tissue response curves in healthy tissue and in brain tumours and confirmed that DGE MRI enables differentiation of tumour from normal tissue, but that motion-related artefacts may complicate the interpretation. We developed a post-processing method for DGE MRI based on visualization of tissue response curve types with different characteristic temporal enhancement patterns. Finally, we developed a model for kinetic analysis of DGE MRI, accounting for the different signal origin and uptake kinetics of normal D-glucose. <br/><br/>In summary, DGE MRI has potential for tumour detection in humans and can provide information on glucose delivery, transport, and metabolism. However, further optimization of imaging and post-processing techniques is necessary, especially at lower field strengths.}},
author = {{Seidemo, Anina}},
isbn = {{978-91-8039-554-0}},
keywords = {{Chemical exchange saturation transfer (CEST); Dynamic glucose enhanced (DGE) MRI; GlucoCEST; MRI; D-glucose; Fysicumarkivet A:2023:Seidemo}},
language = {{eng}},
month = {{04}},
publisher = {{Lund University}},
school = {{Lund University}},
title = {{Dynamic glucose enhanced chemical exchange saturation transfer MRI : Optimization of methodology and characterization of cerebral transport kinetics}},
url = {{https://lup.lub.lu.se/search/files/142191274/Kappa_Anina_Seidemo_2023_utan_sign.pdf}},
year = {{2023}},
}