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Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time

Seidemo, Anina LU ; Lehmann, Patrick M. LU orcid ; Rydhög, Anna LU ; Wirestam, Ronnie LU orcid ; Helms, Gunther LU orcid ; Zhang, Yi ; Yadav, Nirbhay N. ; Sundgren, Pia C. LU orcid ; van Zijl, Peter C. M. and Knutsson, Linda LU orcid (2022) In NMR in Biomedicine 35(2). p.4624-4624
Abstract
Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1 and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning protocols, as a step towards making the glucose chemical exchange saturation transfer (glucoCEST) protocol more robust. Two different infusion durations (1.5 and 4.0 min) and saturation frequency offsets (1.2 and 2.0 ppm) were used. The effect of... (More)
Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1 and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning protocols, as a step towards making the glucose chemical exchange saturation transfer (glucoCEST) protocol more robust. Two different infusion durations (1.5 and 4.0 min) and saturation frequency offsets (1.2 and 2.0 ppm) were used. The effect of subject motion on the DGE signal was studied by using motion estimates retrieved from standard retrospective motion correction to create pseudo-DGE maps, where the apparent DGE signal changes were entirely caused by motion. Furthermore, the DGE AIFs were compared with venous blood glucose levels. A significant difference (p = 0.03) between arterial baseline and postinfusion DGE signal was found after D-glucose infusion. The results indicate that the measured DGE AIF signal change depends on both motion and blood glucose concentration change, emphasizing the need for sufficient motion correction in glucoCEST imaging. Finally, we conclude that a longer infusion duration (e.g. 3–4 min) should preferably be used in glucoCEST experiments, because it can minimize the glucose infusion side effects without negatively affecting the DGE signal change. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AIF, CEST, DGE, D-glucose, glucoCEST, motion correction, perfusion
in
NMR in Biomedicine
volume
35
issue
2
article number
e4624
pages
4624 - 4624
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85115833486
  • pmid:34585813
ISSN
0952-3480
DOI
10.1002/nbm.4624
project
Natural sugar as an MRI contrast agent for cancer diagnosis
language
English
LU publication?
yes
id
23b4bce6-1362-496e-be50-82610f48db3a
alternative location
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/nbm.4624
date added to LUP
2021-09-29 20:08:56
date last changed
2024-05-17 13:44:27
@article{23b4bce6-1362-496e-be50-82610f48db3a,
  abstract     = {{Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1 and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning protocols, as a step towards making the glucose chemical exchange saturation transfer (glucoCEST) protocol more robust. Two different infusion durations (1.5 and 4.0 min) and saturation frequency offsets (1.2 and 2.0 ppm) were used. The effect of subject motion on the DGE signal was studied by using motion estimates retrieved from standard retrospective motion correction to create pseudo-DGE maps, where the apparent DGE signal changes were entirely caused by motion. Furthermore, the DGE AIFs were compared with venous blood glucose levels. A significant difference (p = 0.03) between arterial baseline and postinfusion DGE signal was found after D-glucose infusion. The results indicate that the measured DGE AIF signal change depends on both motion and blood glucose concentration change, emphasizing the need for sufficient motion correction in glucoCEST imaging. Finally, we conclude that a longer infusion duration (e.g. 3–4 min) should preferably be used in glucoCEST experiments, because it can minimize the glucose infusion side effects without negatively affecting the DGE signal change.}},
  author       = {{Seidemo, Anina and Lehmann, Patrick M. and Rydhög, Anna and Wirestam, Ronnie and Helms, Gunther and Zhang, Yi and Yadav, Nirbhay N. and Sundgren, Pia C. and van Zijl, Peter C. M. and Knutsson, Linda}},
  issn         = {{0952-3480}},
  keywords     = {{AIF; CEST; DGE; D-glucose; glucoCEST; motion correction; perfusion}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{4624--4624}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{NMR in Biomedicine}},
  title        = {{Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time}},
  url          = {{http://dx.doi.org/10.1002/nbm.4624}},
  doi          = {{10.1002/nbm.4624}},
  volume       = {{35}},
  year         = {{2022}},
}