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Test-retest analysis of cerebral oxygen extraction estimates in healthy volunteers : comparison of methods based on quantitative susceptibility mapping and dynamic susceptibility contrast magnetic resonance imaging

Wirestam, Ronnie LU orcid ; Lundberg, Anna LU ; Chakwizira, Arthur LU ; van Westen, Danielle LU orcid ; Knutsson, Linda LU orcid and Lind, Emelie LU (2022) In Heliyon 8(12).
Abstract

Background: Estimation of the oxygen extraction fraction (OEF) by quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI) is promising but requires systematic evaluation. Extraction of OEF-related information from the tissue residue function in dynamic susceptibility contrast MRI (DSC-MRI) has also been proposed. In this study, whole-brain OEF repeatability was investigated, as well as the relationships between QSM-based OEF and DSC-MRI-based parameters, i.e., mean transit time (MTT) and an oxygen extraction index, referred to as apparent OEF (AOEF). Method: Test-retest data were obtained from 20 healthy volunteers at 3 T. QSM maps were reconstructed from 3D gradient-echo MRI phase data, using morphology-enabled... (More)

Background: Estimation of the oxygen extraction fraction (OEF) by quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI) is promising but requires systematic evaluation. Extraction of OEF-related information from the tissue residue function in dynamic susceptibility contrast MRI (DSC-MRI) has also been proposed. In this study, whole-brain OEF repeatability was investigated, as well as the relationships between QSM-based OEF and DSC-MRI-based parameters, i.e., mean transit time (MTT) and an oxygen extraction index, referred to as apparent OEF (AOEF). Method: Test-retest data were obtained from 20 healthy volunteers at 3 T. QSM maps were reconstructed from 3D gradient-echo MRI phase data, using morphology-enabled dipole inversion. DSC-MRI was accomplished using gradient-echo MRI at a temporal resolution of 1.24 s. Results: The whole-brain QSM-based OEF was (40.4±4.8) % and, in combination with a previously published cerebral blood flow (CBF) estimate, this corresponds to a cerebral metabolic rate of oxygen level of CMRO2 = 3.36 ml O2/min/100 g. The intra-class correlation coefficient [ICC(2,1)] for OEF test-retest data was 0.73. The MTT-versus-OEF and AOEF-versus-OEF relationships showed correlation coefficients of 0.61 (p = 0.004) and 0.52 (p = 0.019), respectively. Discussion: QSM-based OEF showed a convincing absolute level and good test-retest results in terms of the ICC. Moderate to good correlations between QSM-based OEF and DSC-MRI-based parameters were observed. The present results constitute an indicator of the level of robustness that can be achieved without applying extraordinary resources in terms of MRI equipment, imaging protocol, QSM reconstruction, and OEF analysis.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebrovascular circulation, Contrast media, Hemodynamics, Magnetic resonance imaging, Magnetometry, Oxygen consumption
in
Heliyon
volume
8
issue
12
article number
e12364
publisher
Elsevier
external identifiers
  • pmid:36590544
  • scopus:85144787210
ISSN
2405-8440
DOI
10.1016/j.heliyon.2022.e12364
language
English
LU publication?
yes
id
f7e8c80c-b363-4bce-afa5-aa466123d121
date added to LUP
2023-01-05 11:49:03
date last changed
2024-04-04 15:25:26
@article{f7e8c80c-b363-4bce-afa5-aa466123d121,
  abstract     = {{<p>Background: Estimation of the oxygen extraction fraction (OEF) by quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI) is promising but requires systematic evaluation. Extraction of OEF-related information from the tissue residue function in dynamic susceptibility contrast MRI (DSC-MRI) has also been proposed. In this study, whole-brain OEF repeatability was investigated, as well as the relationships between QSM-based OEF and DSC-MRI-based parameters, i.e., mean transit time (MTT) and an oxygen extraction index, referred to as apparent OEF (AOEF). Method: Test-retest data were obtained from 20 healthy volunteers at 3 T. QSM maps were reconstructed from 3D gradient-echo MRI phase data, using morphology-enabled dipole inversion. DSC-MRI was accomplished using gradient-echo MRI at a temporal resolution of 1.24 s. Results: The whole-brain QSM-based OEF was (40.4±4.8) % and, in combination with a previously published cerebral blood flow (CBF) estimate, this corresponds to a cerebral metabolic rate of oxygen level of CMRO<sub>2</sub> = 3.36 ml O<sub>2</sub>/min/100 g. The intra-class correlation coefficient [ICC(2,1)] for OEF test-retest data was 0.73. The MTT-versus-OEF and AOEF-versus-OEF relationships showed correlation coefficients of 0.61 (p = 0.004) and 0.52 (p = 0.019), respectively. Discussion: QSM-based OEF showed a convincing absolute level and good test-retest results in terms of the ICC. Moderate to good correlations between QSM-based OEF and DSC-MRI-based parameters were observed. The present results constitute an indicator of the level of robustness that can be achieved without applying extraordinary resources in terms of MRI equipment, imaging protocol, QSM reconstruction, and OEF analysis.</p>}},
  author       = {{Wirestam, Ronnie and Lundberg, Anna and Chakwizira, Arthur and van Westen, Danielle and Knutsson, Linda and Lind, Emelie}},
  issn         = {{2405-8440}},
  keywords     = {{Cerebrovascular circulation; Contrast media; Hemodynamics; Magnetic resonance imaging; Magnetometry; Oxygen consumption}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{Test-retest analysis of cerebral oxygen extraction estimates in healthy volunteers : comparison of methods based on quantitative susceptibility mapping and dynamic susceptibility contrast magnetic resonance imaging}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2022.e12364}},
  doi          = {{10.1016/j.heliyon.2022.e12364}},
  volume       = {{8}},
  year         = {{2022}},
}