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Health monitoring in birds using bio-loggers and whole blood transcriptomics

Jax, Elinor ; Müller, Inge ; Börno, Stefan ; Borlinghaus, Hanna ; Eriksson, Gustaw LU ; Fricke, Evi ; Timmermann, Bernd ; Pendl, Helene ; Fiedler, Wolfgang and Klein, Karsten , et al. (2021) In Scientific Reports 11(1).
Abstract

Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across... (More)

Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
11
issue
1
article number
10815
publisher
Nature Publishing Group
external identifiers
  • pmid:34031452
  • scopus:85106731353
ISSN
2045-2322
DOI
10.1038/s41598-021-90212-8
language
English
LU publication?
yes
id
f83a705d-f3a4-4f97-9f99-44567b94606d
date added to LUP
2021-06-14 15:59:12
date last changed
2024-06-15 12:32:16
@article{f83a705d-f3a4-4f97-9f99-44567b94606d,
  abstract     = {{<p>Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.</p>}},
  author       = {{Jax, Elinor and Müller, Inge and Börno, Stefan and Borlinghaus, Hanna and Eriksson, Gustaw and Fricke, Evi and Timmermann, Bernd and Pendl, Helene and Fiedler, Wolfgang and Klein, Karsten and Schreiber, Falk and Wikelski, Martin and Magor, Katharine E. and Kraus, Robert H.S.}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Health monitoring in birds using bio-loggers and whole blood transcriptomics}},
  url          = {{http://dx.doi.org/10.1038/s41598-021-90212-8}},
  doi          = {{10.1038/s41598-021-90212-8}},
  volume       = {{11}},
  year         = {{2021}},
}