Health monitoring in birds using bio-loggers and whole blood transcriptomics
(2021) In Scientific Reports 11(1).- Abstract
Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across... (More)
Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.
(Less)
- author
- organization
- publishing date
- 2021-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 11
- issue
- 1
- article number
- 10815
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:34031452
- scopus:85106731353
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-021-90212-8
- language
- English
- LU publication?
- yes
- id
- f83a705d-f3a4-4f97-9f99-44567b94606d
- date added to LUP
- 2021-06-14 15:59:12
- date last changed
- 2024-09-07 20:35:48
@article{f83a705d-f3a4-4f97-9f99-44567b94606d, abstract = {{<p>Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.</p>}}, author = {{Jax, Elinor and Müller, Inge and Börno, Stefan and Borlinghaus, Hanna and Eriksson, Gustaw and Fricke, Evi and Timmermann, Bernd and Pendl, Helene and Fiedler, Wolfgang and Klein, Karsten and Schreiber, Falk and Wikelski, Martin and Magor, Katharine E. and Kraus, Robert H.S.}}, issn = {{2045-2322}}, language = {{eng}}, month = {{12}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Health monitoring in birds using bio-loggers and whole blood transcriptomics}}, url = {{http://dx.doi.org/10.1038/s41598-021-90212-8}}, doi = {{10.1038/s41598-021-90212-8}}, volume = {{11}}, year = {{2021}}, }