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Plasma Levels of Hepcidin and Reticulocyte Haemoglobin during Septic Shock

Olinder, Jon LU ; Ehinger, Daniel LU orcid ; Liljenborg, Erik ; Herwald, Heiko LU orcid and Rydén, Cecilia LU (2020) In Journal of Innate Immunity 12(6). p.448-460
Abstract

Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring rapid changes in hepcidin and Ret-He in patients with septic shock receiving adequate antibiotic treatment. Fifteen patients, included within an hour of admission to the intensive care unit, were evaluated by microbiological tests and cultures, Sequential Organ Failure Assessment score, and plasma levels of hepcidin, Ret-He, heparin-binding... (More)

Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring rapid changes in hepcidin and Ret-He in patients with septic shock receiving adequate antibiotic treatment. Fifteen patients, included within an hour of admission to the intensive care unit, were evaluated by microbiological tests and cultures, Sequential Organ Failure Assessment score, and plasma levels of hepcidin, Ret-He, heparin-binding protein (HBP), leucocytes, C-reactive protein, procalcitonin (PCT), and lactate. Samples were taken every morning for 7 consecutive days. Maximal levels of hepcidin (median 61 nmol/L; reference 1-12 nmol/L) were seen at the time of inclusion, then declining steadily similar to PCT and lactate levels. Ret-He values decreased transiently in response to increased hepcidin, normalization occurred at 96 h upon decrease of hepcidin levels. Maximal levels of HBP were noted 24 h after inclusion. In conclusion, hepcidin promptly declined within the first 24 h in patients with septic shock receiving adequate antibiotic treatment in contrast to Ret-He and HBP.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
12
issue
6
pages
13 pages
publisher
Karger
external identifiers
  • scopus:85092253963
  • pmid:32950976
ISSN
1662-811X
DOI
10.1159/000508561
language
English
LU publication?
yes
additional info
© 2020 The Author(s) Published by S. Karger AG, Basel.
id
f84d9861-e02e-45e0-b20a-3f97a5da0f78
date added to LUP
2020-09-24 12:31:34
date last changed
2024-10-31 11:16:20
@article{f84d9861-e02e-45e0-b20a-3f97a5da0f78,
  abstract     = {{<p>Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring rapid changes in hepcidin and Ret-He in patients with septic shock receiving adequate antibiotic treatment. Fifteen patients, included within an hour of admission to the intensive care unit, were evaluated by microbiological tests and cultures, Sequential Organ Failure Assessment score, and plasma levels of hepcidin, Ret-He, heparin-binding protein (HBP), leucocytes, C-reactive protein, procalcitonin (PCT), and lactate. Samples were taken every morning for 7 consecutive days. Maximal levels of hepcidin (median 61 nmol/L; reference 1-12 nmol/L) were seen at the time of inclusion, then declining steadily similar to PCT and lactate levels. Ret-He values decreased transiently in response to increased hepcidin, normalization occurred at 96 h upon decrease of hepcidin levels. Maximal levels of HBP were noted 24 h after inclusion. In conclusion, hepcidin promptly declined within the first 24 h in patients with septic shock receiving adequate antibiotic treatment in contrast to Ret-He and HBP.</p>}},
  author       = {{Olinder, Jon and Ehinger, Daniel and Liljenborg, Erik and Herwald, Heiko and Rydén, Cecilia}},
  issn         = {{1662-811X}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{448--460}},
  publisher    = {{Karger}},
  series       = {{Journal of Innate Immunity}},
  title        = {{Plasma Levels of Hepcidin and Reticulocyte Haemoglobin during Septic Shock}},
  url          = {{http://dx.doi.org/10.1159/000508561}},
  doi          = {{10.1159/000508561}},
  volume       = {{12}},
  year         = {{2020}},
}