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Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats

Tomé-Carneiro, Joao ; Carmen Crespo, M. ; Burgos-Ramos, Emma ; Tomas-Zapico, Cristina ; García-Serrano, Alba LU ; Castro-Gómez, Pilar ; Venero, Cesar ; Pereda-Pérez, Inmaculada ; Baliyan, Shishir and Valencia, Azucena , et al. (2018) In Molecular Neurobiology 55(9). p.7285-7296
Abstract

Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (KOC), buttermilk fat globule membranes (BMFC), and a combination of both in aged rats. After 3 months of supplementation, although all groups of animals showed clear signs of peripheral insulin resistance, the combination of KOC and... (More)

Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (KOC), buttermilk fat globule membranes (BMFC), and a combination of both in aged rats. After 3 months of supplementation, although all groups of animals showed clear signs of peripheral insulin resistance, the combination of KOC and BMFC was able to improve peripheral insulin sensitivity. We also explored brain energy balance. Interestingly, the hippocampus of supplemented rats—mainly when supplemented with BMFC or the combination of KOC and BMFC—showed an increase in intracellular adenosine triphosphate (ATP) levels, whereas no difference was observed in the cerebral cortex. Moreover, we found a significant increase of brain-derived neurotrophic factor (BDNF) in the hippocampus of BMFC+KO animals. In summary, dietary supplementation with KOC and/or BMFC improves peripheral and central insulin resistance, suggesting that their administration could delay the onset of these phenomena. Moreover, n-3 fatty acids (FAs) ingested as phospholipids increase BDNF levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. Thus, dietary supplementation with n-3 FAs could protect local protein synthesis and energy balance within dendrites, favoring neuronal health and delaying cognitive decline associated to age-related disrepair.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Buttermilk, Hippocampus, Insulin, Krill oil, Phospholipids
in
Molecular Neurobiology
volume
55
issue
9
pages
12 pages
publisher
Humana Press
external identifiers
  • scopus:85045129931
  • pmid:29397560
ISSN
0893-7648
DOI
10.1007/s12035-018-0934-y
language
English
LU publication?
no
id
f8551014-5a5d-406c-933f-43a0f222b1c9
date added to LUP
2020-02-05 15:14:53
date last changed
2020-11-10 04:41:16
@article{f8551014-5a5d-406c-933f-43a0f222b1c9,
  abstract     = {<p>Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (KOC), buttermilk fat globule membranes (BMFC), and a combination of both in aged rats. After 3 months of supplementation, although all groups of animals showed clear signs of peripheral insulin resistance, the combination of KOC and BMFC was able to improve peripheral insulin sensitivity. We also explored brain energy balance. Interestingly, the hippocampus of supplemented rats—mainly when supplemented with BMFC or the combination of KOC and BMFC—showed an increase in intracellular adenosine triphosphate (ATP) levels, whereas no difference was observed in the cerebral cortex. Moreover, we found a significant increase of brain-derived neurotrophic factor (BDNF) in the hippocampus of BMFC+KO animals. In summary, dietary supplementation with KOC and/or BMFC improves peripheral and central insulin resistance, suggesting that their administration could delay the onset of these phenomena. Moreover, n-3 fatty acids (FAs) ingested as phospholipids increase BDNF levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. Thus, dietary supplementation with n-3 FAs could protect local protein synthesis and energy balance within dendrites, favoring neuronal health and delaying cognitive decline associated to age-related disrepair.</p>},
  author       = {Tomé-Carneiro, Joao and Carmen Crespo, M. and Burgos-Ramos, Emma and Tomas-Zapico, Cristina and García-Serrano, Alba and Castro-Gómez, Pilar and Venero, Cesar and Pereda-Pérez, Inmaculada and Baliyan, Shishir and Valencia, Azucena and Fontecha, Javier and Dávalos, Alberto and Visioli, Francesco},
  issn         = {0893-7648},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {7285--7296},
  publisher    = {Humana Press},
  series       = {Molecular Neurobiology},
  title        = {Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats},
  url          = {http://dx.doi.org/10.1007/s12035-018-0934-y},
  doi          = {10.1007/s12035-018-0934-y},
  volume       = {55},
  year         = {2018},
}