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Aortic Stiffness, Inflammation, and Incidence of Cardiovascular Events in Elderly Participants From the General Population

Nilsson Wadström, Benjamin ; Persson, Margaretha LU orcid ; Engström, Gunnar LU and Nilsson, Peter M. LU (2022) In Angiology 73(1). p.51-59
Abstract

Low-grade inflammation and arterial stiffness are key factors in the development of vascular aging. However, the interplay between arterial stiffness and inflammation for cardiovascular (CV) disease is unclear. Aortic pulse wave velocity (aPWV) and the inflammatory markers, high-sensitivity C-reactive protein (CRP) and orosomucoid, were measured in 2710 participants (median age: 72 years). These participants were followed up for a mean of 7.6 years for a composite CV disease end point. Per 1 interquartile range increment of CRP and orosomucoid, respectively, aPWV increased by 0.19 m/s (95% CI: 0.07-0.32) and 0.19 m/s (0.11-0.27), after multifactorial adjustment. Mediation analysis showed that aPWV, after multifactorial adjustment,... (More)

Low-grade inflammation and arterial stiffness are key factors in the development of vascular aging. However, the interplay between arterial stiffness and inflammation for cardiovascular (CV) disease is unclear. Aortic pulse wave velocity (aPWV) and the inflammatory markers, high-sensitivity C-reactive protein (CRP) and orosomucoid, were measured in 2710 participants (median age: 72 years). These participants were followed up for a mean of 7.6 years for a composite CV disease end point. Per 1 interquartile range increment of CRP and orosomucoid, respectively, aPWV increased by 0.19 m/s (95% CI: 0.07-0.32) and 0.19 m/s (0.11-0.27), after multifactorial adjustment. Mediation analysis showed that aPWV, after multifactorial adjustment, mediated 8% (−4, 20) of the CV disease risk associated with CRP and 8% (−4, 18) of orosomucoid risk. The associated risk increased with combinations of high aPWV and high CRP or orosomucoid. We found no evidence that arterial PWV acted as an important mediator of the relationship between systemic inflammation and CV disease risk in this elderly population. The results instead indicate an additive effect. Our study supports the view that arterial stiffness and chronic inflammation affects CV risk mainly through separate causal pathways.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aorta, arterial stiffness, arteriosclerosis, C-reactive protein, inflammation, orosomucoid, pulse wave velocity
in
Angiology
volume
73
issue
1
pages
51 - 59
publisher
SAGE Publications
external identifiers
  • pmid:34013787
  • scopus:85106436105
ISSN
0003-3197
DOI
10.1177/00033197211017406
language
English
LU publication?
yes
id
f87ee17e-9bff-4577-92ab-2ad107990800
date added to LUP
2021-06-15 15:43:50
date last changed
2024-06-29 13:40:07
@article{f87ee17e-9bff-4577-92ab-2ad107990800,
  abstract     = {{<p>Low-grade inflammation and arterial stiffness are key factors in the development of vascular aging. However, the interplay between arterial stiffness and inflammation for cardiovascular (CV) disease is unclear. Aortic pulse wave velocity (aPWV) and the inflammatory markers, high-sensitivity C-reactive protein (CRP) and orosomucoid, were measured in 2710 participants (median age: 72 years). These participants were followed up for a mean of 7.6 years for a composite CV disease end point. Per 1 interquartile range increment of CRP and orosomucoid, respectively, aPWV increased by 0.19 m/s (95% CI: 0.07-0.32) and 0.19 m/s (0.11-0.27), after multifactorial adjustment. Mediation analysis showed that aPWV, after multifactorial adjustment, mediated 8% (−4, 20) of the CV disease risk associated with CRP and 8% (−4, 18) of orosomucoid risk. The associated risk increased with combinations of high aPWV and high CRP or orosomucoid. We found no evidence that arterial PWV acted as an important mediator of the relationship between systemic inflammation and CV disease risk in this elderly population. The results instead indicate an additive effect. Our study supports the view that arterial stiffness and chronic inflammation affects CV risk mainly through separate causal pathways.</p>}},
  author       = {{Nilsson Wadström, Benjamin and Persson, Margaretha and Engström, Gunnar and Nilsson, Peter M.}},
  issn         = {{0003-3197}},
  keywords     = {{aorta; arterial stiffness; arteriosclerosis; C-reactive protein; inflammation; orosomucoid; pulse wave velocity}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{51--59}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Aortic Stiffness, Inflammation, and Incidence of Cardiovascular Events in Elderly Participants From the General Population}},
  url          = {{http://dx.doi.org/10.1177/00033197211017406}},
  doi          = {{10.1177/00033197211017406}},
  volume       = {{73}},
  year         = {{2022}},
}