Various regimens for prophylactic treatment of patients with haemophilia
Schwarz, Rudolf ; Ljung, Rolf LU
and Tedgård, Ulf
LU
(2015)
In European Journal of Haematology
94.
p.11-16
- Abstract
- Haemophilia prophylaxis is superior to on-demand treatment to prevent joint damage. High-dose prophylaxis' as used in Sweden is more effective in preventing arthropathy than an intermediate-dose regimen' (the Netherlands) and the Canadian tailored primary prophylaxis. Prophylaxis may reduce the risk of developing inhibitors. There is no difference in inhibitor risk between plasma derived and recombinant factor VIII (rFVIII) products but the Rodin study showed increased risk with second-generation rFVIII products. MRI is a new and very sensitive tool to detect the symptoms of early arthropathy but some results (soft tissue changes in bleed-free joints') still need to be investigated. Ultrasound is a very helpful method to aid diagnosis... (More)
- Haemophilia prophylaxis is superior to on-demand treatment to prevent joint damage. High-dose prophylaxis' as used in Sweden is more effective in preventing arthropathy than an intermediate-dose regimen' (the Netherlands) and the Canadian tailored primary prophylaxis. Prophylaxis may reduce the risk of developing inhibitors. There is no difference in inhibitor risk between plasma derived and recombinant factor VIII (rFVIII) products but the Rodin study showed increased risk with second-generation rFVIII products. MRI is a new and very sensitive tool to detect the symptoms of early arthropathy but some results (soft tissue changes in bleed-free joints') still need to be investigated. Ultrasound is a very helpful method to aid diagnosis especially during the acute phase of a bleed. The risk of infection with central venous access remains a matter of debate. A fully implanted central venous access device (CVAD) has a significant lower risk of infection compared to external CVADs. Patient's age under 6yr and inhibitor presence are additional risk factors for infections. The role of arteriovenous fistulae needs to be investigated because significant complications have been reported. Disease-specific quality of life instruments are complementary to generic instruments evaluating QoL in patients with haemophilia and have become important health outcome measures. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5075990
- author
- Schwarz, Rudolf
; Ljung, Rolf
LU
and Tedgård, Ulf
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prophylaxis, children, haemophilia, treatment, inhibitors
- in
- European Journal of Haematology
- volume
- 94
- pages
- 11 - 16
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000347371100004
- scopus:84920265049
- pmid:25560789
- ISSN
- 1600-0609
- DOI
- 10.1111/ejh.12496
- language
- English
- LU publication?
- yes
- id
- f8b97399-b131-4433-ad52-c33165614d92 (old id 5075990)
- date added to LUP
- 2016-04-01 11:08:50
- date last changed
- 2022-01-26 05:50:17
@article{f8b97399-b131-4433-ad52-c33165614d92,
abstract = {{Haemophilia prophylaxis is superior to on-demand treatment to prevent joint damage. High-dose prophylaxis' as used in Sweden is more effective in preventing arthropathy than an intermediate-dose regimen' (the Netherlands) and the Canadian tailored primary prophylaxis. Prophylaxis may reduce the risk of developing inhibitors. There is no difference in inhibitor risk between plasma derived and recombinant factor VIII (rFVIII) products but the Rodin study showed increased risk with second-generation rFVIII products. MRI is a new and very sensitive tool to detect the symptoms of early arthropathy but some results (soft tissue changes in bleed-free joints') still need to be investigated. Ultrasound is a very helpful method to aid diagnosis especially during the acute phase of a bleed. The risk of infection with central venous access remains a matter of debate. A fully implanted central venous access device (CVAD) has a significant lower risk of infection compared to external CVADs. Patient's age under 6yr and inhibitor presence are additional risk factors for infections. The role of arteriovenous fistulae needs to be investigated because significant complications have been reported. Disease-specific quality of life instruments are complementary to generic instruments evaluating QoL in patients with haemophilia and have become important health outcome measures.}},
author = {{Schwarz, Rudolf and Ljung, Rolf and Tedgård, Ulf}},
issn = {{1600-0609}},
keywords = {{prophylaxis; children; haemophilia; treatment; inhibitors}},
language = {{eng}},
pages = {{11--16}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{Various regimens for prophylactic treatment of patients with haemophilia}},
url = {{http://dx.doi.org/10.1111/ejh.12496}},
doi = {{10.1111/ejh.12496}},
volume = {{94}},
year = {{2015}},
}