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A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm

Fatemi, Shahab LU ; Acosta, Stefan LU orcid ; Zarrouk, Moncef LU ; Nilsson, Peter M. LU and Gottsäter, Anders LU (2023) In Cardiovascular Endocrinology and Metabolism 12(4).
Abstract

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal abdominal aortic diameter underwent examination of glucose metabolism and arterial stiffness. Results Men with AAA had higher BMI, waist-hip ratio (WHR), frequency of DM, haemoglobin A1c, smoking exposure, and plasma insulin levels at 0, 60 and 120 min during OGTT compared to those without. The increase in p-insulin (P < 0.001)... (More)

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal abdominal aortic diameter underwent examination of glucose metabolism and arterial stiffness. Results Men with AAA had higher BMI, waist-hip ratio (WHR), frequency of DM, haemoglobin A1c, smoking exposure, and plasma insulin levels at 0, 60 and 120 min during OGTT compared to those without. The increase in p-insulin (P < 0.001) after OGTT was also higher in men with AAA, adjusted for smoking, WHR, and nadir value of p-insulin. In analyses adjusted for smoking, use of lipid-lowering agents, and WHR, the increase in p-insulin at 2-hours (P = 0.006) after OGTT and p-homocysteine were associated with abdominal aortic diameter. There were no differences between groups in aortic stiffness or skin autofluorescence Advanced Glycation End products. Conclusion In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
abdominal aortic aneurysm, aortic diameter, arterial stiffness, atherosclerosis, diabetes mellitus, hyperinsulinaemia, metabolic syndrome, screening
in
Cardiovascular Endocrinology and Metabolism
volume
12
issue
4
article number
e0290
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85206557070
ISSN
2574-0954
DOI
10.1097/XCE.0000000000000290
language
English
LU publication?
yes
id
f8d98d42-145f-4d17-a6e3-3e6d0ead27ae
date added to LUP
2025-01-03 11:29:13
date last changed
2025-10-14 12:00:58
@article{f8d98d42-145f-4d17-a6e3-3e6d0ead27ae,
  abstract     = {{<p>Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal abdominal aortic diameter underwent examination of glucose metabolism and arterial stiffness. Results Men with AAA had higher BMI, waist-hip ratio (WHR), frequency of DM, haemoglobin A<sub>1c</sub>, smoking exposure, and plasma insulin levels at 0, 60 and 120 min during OGTT compared to those without. The increase in p-insulin (P &lt; 0.001) after OGTT was also higher in men with AAA, adjusted for smoking, WHR, and nadir value of p-insulin. In analyses adjusted for smoking, use of lipid-lowering agents, and WHR, the increase in p-insulin at 2-hours (P = 0.006) after OGTT and p-homocysteine were associated with abdominal aortic diameter. There were no differences between groups in aortic stiffness or skin autofluorescence Advanced Glycation End products. Conclusion In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.</p>}},
  author       = {{Fatemi, Shahab and Acosta, Stefan and Zarrouk, Moncef and Nilsson, Peter M. and Gottsäter, Anders}},
  issn         = {{2574-0954}},
  keywords     = {{abdominal aortic aneurysm; aortic diameter; arterial stiffness; atherosclerosis; diabetes mellitus; hyperinsulinaemia; metabolic syndrome; screening}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{4}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Cardiovascular Endocrinology and Metabolism}},
  title        = {{A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm}},
  url          = {{http://dx.doi.org/10.1097/XCE.0000000000000290}},
  doi          = {{10.1097/XCE.0000000000000290}},
  volume       = {{12}},
  year         = {{2023}},
}