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Digitalization in biopharmaceutical downstream processes

Espinoza, Daniel LU (2024)
Abstract
Biopharmaceuticals are highly valued for their ability to specifically and efficiently treat diseases. However, they require rigorous purification that involves complex unit operations to reach the levels of purity necessitated for use in patients. Maintaining this purity while recovering as much of the valuable biopharmaceutical as possible is the core challenge in biopharmaceutical downstream processing.

Digitalization is a growing trend that has proven to increase efficiency in other manufacturing industries by implementing advanced automation based on high-quality data, automatic control tools and digital
twin technology. This thesis examines the application of digitalization to the biopharmaceutical downstream process... (More)
Biopharmaceuticals are highly valued for their ability to specifically and efficiently treat diseases. However, they require rigorous purification that involves complex unit operations to reach the levels of purity necessitated for use in patients. Maintaining this purity while recovering as much of the valuable biopharmaceutical as possible is the core challenge in biopharmaceutical downstream processing.

Digitalization is a growing trend that has proven to increase efficiency in other manufacturing industries by implementing advanced automation based on high-quality data, automatic control tools and digital
twin technology. This thesis examines the application of digitalization to the biopharmaceutical downstream process through the lens of six case studies. The use of digital twins, automated data acquisition and Internet-of-Things connectivity is showcased, shedding light on how digitalization can
be used to achieve more efficient, robust production of biopharmaceuticals. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Associate Prof. Papathanasiou, Maria, Imperial College London, United Kingdom.
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Biopharmaceuticals, Digitalization, Simulation, Modeling & Simulation Technology, Digital Twins, Automation, Downstream Processing, Chromatography
pages
166 pages
publisher
Department of Process and Life Science Engineering, Lund University.
defense location
Lecture Hall KC:C, Kemicentrum, Naturvetarvägen 14, Faculty of Engineering LTH, Lund University, Lund.
defense date
2024-12-13 10:00:00
ISBN
978-91-8096-082-3
978-91-8096-083-0
language
English
LU publication?
yes
id
f936d3e3-244e-4f3b-812a-6866d82a1eee
date added to LUP
2024-11-06 16:32:18
date last changed
2025-04-04 14:41:29
@phdthesis{f936d3e3-244e-4f3b-812a-6866d82a1eee,
  abstract     = {{Biopharmaceuticals are highly valued for their ability to specifically and efficiently treat diseases. However, they require rigorous purification that involves complex unit operations to reach the levels of purity necessitated for use in patients. Maintaining this purity while recovering as much of the valuable biopharmaceutical as possible is the core challenge in biopharmaceutical downstream processing. <br/><br/>Digitalization is a growing trend that has proven to increase efficiency in other manufacturing industries by implementing advanced automation based on high-quality data, automatic control tools and digital <br/>twin technology. This thesis examines the application of digitalization to the biopharmaceutical downstream process through the lens of six case studies. The use of digital twins, automated data acquisition and Internet-of-Things connectivity is showcased, shedding light on how digitalization can <br/>be used to achieve more efficient, robust production of biopharmaceuticals.}},
  author       = {{Espinoza, Daniel}},
  isbn         = {{978-91-8096-082-3}},
  keywords     = {{Biopharmaceuticals; Digitalization; Simulation; Modeling & Simulation Technology; Digital Twins; Automation; Downstream Processing; Chromatography}},
  language     = {{eng}},
  publisher    = {{Department of Process and Life Science Engineering, Lund University.}},
  school       = {{Lund University}},
  title        = {{Digitalization in biopharmaceutical downstream processes}},
  url          = {{https://lup.lub.lu.se/search/files/199636754/Daniel_Espinoza_-_WEBB.pdf}},
  year         = {{2024}},
}