Elective caesarean : Does delay in cord clamping for 30 s ensure sufficient iron stores at 4 months of age? A historical cohort control study
Andersson, Ola LU
; Hellström-Westas, Lena
LU
and Domellöf, Magnus
(2016)
In BMJ Open
6(11).
- Abstract
Objective: To compare iron stores in infants born after elective caesarean section (CS) and a 30 s delay of umbilical cord clamping with those born vaginally after early (≤10 s) or delayed (≥180 s) cord clamping. Design: Prospective observational study with historical control. Setting: Swedish county hospital. Population: 64 infants born after elective CS were compared with a historical control of 166 early clamped and 168 delayed clamped after vaginal birth. Methods: Blood and iron status were measured in blood samples collected at birth, 48-96 hours after birth, 4 and 12 months of age. Primary and secondary outcome measures: Ferritin at 4 months of age was the primary outcome, second outcome measures were other indicators of iron... (More)
Objective: To compare iron stores in infants born after elective caesarean section (CS) and a 30 s delay of umbilical cord clamping with those born vaginally after early (≤10 s) or delayed (≥180 s) cord clamping. Design: Prospective observational study with historical control. Setting: Swedish county hospital. Population: 64 infants born after elective CS were compared with a historical control of 166 early clamped and 168 delayed clamped after vaginal birth. Methods: Blood and iron status were measured in blood samples collected at birth, 48-96 hours after birth, 4 and 12 months of age. Primary and secondary outcome measures: Ferritin at 4 months of age was the primary outcome, second outcome measures were other indicators of iron status, and haemoglobin, at 4 and 12 months of age, as well as respiratory distress at 1 and 6 hours after birth. Results: At 4 months infants born by elective CS had better iron status than those born vaginally subjected to early cord clamping, shown by higher adjusted mean difference of ferritin concentration (39 μg/L (95% CI 10 to 60)) and mean cell volume (1.8 fL (95% CI 0.6 to 3.0)); and lower levels of transferrin receptors (-0.39 mg/L (95% CI -0.69 to -0.08)). No differences were seen between infants born after elective CS and delayed clamped vaginally born infants at 4 months. No differences were found between groups at 12 months of age. Conclusions: Waiting to clamp the umbilical cord for 30 s after elective CS results in higher iron stores at 4 months of age compared with early cord clamping after vaginal birth, and seems to ensure iron status comparable with those achieved after 180 s delayed cord clamping after vaginal birth.
(Less)
- author
- Andersson, Ola
LU
; Hellström-Westas, Lena
LU
and Domellöf, Magnus
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMJ Open
- volume
- 6
- issue
- 11
- article number
- e012995
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:27807089
- scopus:84994525711
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2016-012995
- language
- English
- LU publication?
- no
- id
- f9409e10-a000-4e9f-b08d-c6b6a497aa4f
- date added to LUP
- 2019-06-03 22:12:03
- date last changed
- 2025-05-29 00:31:01
@article{f9409e10-a000-4e9f-b08d-c6b6a497aa4f,
abstract = {{<p>Objective: To compare iron stores in infants born after elective caesarean section (CS) and a 30 s delay of umbilical cord clamping with those born vaginally after early (≤10 s) or delayed (≥180 s) cord clamping. Design: Prospective observational study with historical control. Setting: Swedish county hospital. Population: 64 infants born after elective CS were compared with a historical control of 166 early clamped and 168 delayed clamped after vaginal birth. Methods: Blood and iron status were measured in blood samples collected at birth, 48-96 hours after birth, 4 and 12 months of age. Primary and secondary outcome measures: Ferritin at 4 months of age was the primary outcome, second outcome measures were other indicators of iron status, and haemoglobin, at 4 and 12 months of age, as well as respiratory distress at 1 and 6 hours after birth. Results: At 4 months infants born by elective CS had better iron status than those born vaginally subjected to early cord clamping, shown by higher adjusted mean difference of ferritin concentration (39 μg/L (95% CI 10 to 60)) and mean cell volume (1.8 fL (95% CI 0.6 to 3.0)); and lower levels of transferrin receptors (-0.39 mg/L (95% CI -0.69 to -0.08)). No differences were seen between infants born after elective CS and delayed clamped vaginally born infants at 4 months. No differences were found between groups at 12 months of age. Conclusions: Waiting to clamp the umbilical cord for 30 s after elective CS results in higher iron stores at 4 months of age compared with early cord clamping after vaginal birth, and seems to ensure iron status comparable with those achieved after 180 s delayed cord clamping after vaginal birth.</p>}},
author = {{Andersson, Ola and Hellström-Westas, Lena and Domellöf, Magnus}},
issn = {{2044-6055}},
language = {{eng}},
month = {{11}},
number = {{11}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Open}},
title = {{Elective caesarean : Does delay in cord clamping for 30 s ensure sufficient iron stores at 4 months of age? A historical cohort control study}},
url = {{http://dx.doi.org/10.1136/bmjopen-2016-012995}},
doi = {{10.1136/bmjopen-2016-012995}},
volume = {{6}},
year = {{2016}},
}