Adaptation of signal transduction in brain
(1994) In EXS 71. p.19-28- Abstract
- Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107722
- author
- Alling, Christer LU ; Gustavsson, L ; Larsson, Christer LU ; Lundqvist, C ; Rodriguez, D and Simonsson, Per LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- EXS
- volume
- 71
- pages
- 19 - 28
- publisher
- Birkhäuser
- external identifiers
-
- pmid:8032150
- scopus:0028248606
- ISSN
- 1023-294X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Tumour Cell Biology (013017530), Clinical Chemistry, Malmö (013016000)
- id
- f99e4e56-02d6-45bf-8c1c-97925c6f1cb3 (old id 1107722)
- date added to LUP
- 2016-04-01 16:19:57
- date last changed
- 2024-01-11 06:03:20
@article{f99e4e56-02d6-45bf-8c1c-97925c6f1cb3, abstract = {{Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.}}, author = {{Alling, Christer and Gustavsson, L and Larsson, Christer and Lundqvist, C and Rodriguez, D and Simonsson, Per}}, issn = {{1023-294X}}, language = {{eng}}, pages = {{19--28}}, publisher = {{Birkhäuser}}, series = {{EXS}}, title = {{Adaptation of signal transduction in brain}}, volume = {{71}}, year = {{1994}}, }