Anti-trypanosomal alkaloids from Xymalos monospora
(2006) In Natural Product Communications 1(8). p.619-622- Abstract
- From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/688874
- author
- Ngarnga, Dieudonne ; Tane, Pierre ; Rattendi, Donna ; Bacchi, Cyrus ; Okunji, Christopher C. ; Iwu, Maurice M. ; Schuster, Brian M. and Sterner, Olov LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- trypanosomiasis, antitrypanosomal, alkaloids, Xymalos monospora, monimiaceae, sleeping sickness
- in
- Natural Product Communications
- volume
- 1
- issue
- 8
- pages
- 619 - 622
- publisher
- Natural Products Inc
- external identifiers
-
- wos:000249006500004
- scopus:84900446334
- ISSN
- 1934-578X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- f9c4228b-e4ed-4e8b-8729-d867db18fa17 (old id 688874)
- date added to LUP
- 2016-04-01 12:05:59
- date last changed
- 2022-01-26 22:46:21
@article{f9c4228b-e4ed-4e8b-8729-d867db18fa17, abstract = {{From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.}}, author = {{Ngarnga, Dieudonne and Tane, Pierre and Rattendi, Donna and Bacchi, Cyrus and Okunji, Christopher C. and Iwu, Maurice M. and Schuster, Brian M. and Sterner, Olov}}, issn = {{1934-578X}}, keywords = {{trypanosomiasis; antitrypanosomal; alkaloids; Xymalos monospora; monimiaceae; sleeping sickness}}, language = {{eng}}, number = {{8}}, pages = {{619--622}}, publisher = {{Natural Products Inc}}, series = {{Natural Product Communications}}, title = {{Anti-trypanosomal alkaloids from Xymalos monospora}}, volume = {{1}}, year = {{2006}}, }