Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1
(2020) In Thorax 75(2). p.180-183- Abstract
Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.
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https://lup.lub.lu.se/record/f9fd8851-8510-4ce1-92f4-6486964e5f61
- author
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- COPD pathology, COPD ÀÜ mechanisms
- in
- Thorax
- volume
- 75
- issue
- 2
- pages
- 4 pages
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85078028323
- pmid:31937552
- ISSN
- 0040-6376
- DOI
- 10.1136/thoraxjnl-2019-213200
- language
- English
- LU publication?
- yes
- id
- f9fd8851-8510-4ce1-92f4-6486964e5f61
- date added to LUP
- 2021-01-13 11:50:02
- date last changed
- 2024-06-13 04:56:28
@article{f9fd8851-8510-4ce1-92f4-6486964e5f61, abstract = {{<p>Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.</p>}}, author = {{Brandsma, Corry Anke and Guryev, Victor and Timens, Wim and Ciconelle, Ana and Postma, DIrkje S. and Bischoff, Rainer and Johansson, Maria and Ovchinnikova, Ekaterina S. and Malm, Johan and Marko-Varga, Gyorgy and Fehniger, Thomas E. and Van Den Berge, Maarten and Horvatovich, Peter}}, issn = {{0040-6376}}, keywords = {{COPD pathology; COPD ÀÜ mechanisms}}, language = {{eng}}, number = {{2}}, pages = {{180--183}}, publisher = {{BMJ Publishing Group}}, series = {{Thorax}}, title = {{Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1}}, url = {{http://dx.doi.org/10.1136/thoraxjnl-2019-213200}}, doi = {{10.1136/thoraxjnl-2019-213200}}, volume = {{75}}, year = {{2020}}, }