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Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1

Brandsma, Corry Anke ; Guryev, Victor ; Timens, Wim ; Ciconelle, Ana ; Postma, DIrkje S. ; Bischoff, Rainer ; Johansson, Maria ; Ovchinnikova, Ekaterina S. ; Malm, Johan LU and Marko-Varga, Gyorgy LU , et al. (2020) In Thorax 75(2). p.180-183
Abstract

Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COPD pathology, COPD ÀÜ mechanisms
in
Thorax
volume
75
issue
2
pages
4 pages
publisher
BMJ Publishing Group
external identifiers
  • scopus:85078028323
  • pmid:31937552
ISSN
0040-6376
DOI
10.1136/thoraxjnl-2019-213200
language
English
LU publication?
yes
id
f9fd8851-8510-4ce1-92f4-6486964e5f61
date added to LUP
2021-01-13 11:50:02
date last changed
2024-06-13 04:56:28
@article{f9fd8851-8510-4ce1-92f4-6486964e5f61,
  abstract     = {{<p>Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.</p>}},
  author       = {{Brandsma, Corry Anke and Guryev, Victor and Timens, Wim and Ciconelle, Ana and Postma, DIrkje S. and Bischoff, Rainer and Johansson, Maria and Ovchinnikova, Ekaterina S. and Malm, Johan and Marko-Varga, Gyorgy and Fehniger, Thomas E. and Van Den Berge, Maarten and Horvatovich, Peter}},
  issn         = {{0040-6376}},
  keywords     = {{COPD pathology; COPD ÀÜ mechanisms}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{180--183}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Thorax}},
  title        = {{Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1}},
  url          = {{http://dx.doi.org/10.1136/thoraxjnl-2019-213200}},
  doi          = {{10.1136/thoraxjnl-2019-213200}},
  volume       = {{75}},
  year         = {{2020}},
}