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The dimensionality of between-person differences in white matter microstructure in old age.

Lövdén, Martin LU ; Laukka, Erika Jonsson ; Rieckmann, Anna ; Kalpouzos, Grégoria ; Li, Tie-Qiang ; Jonsson, Tomas ; Wahlund, Lars-Olof ; Fratiglioni, Laura and Bäckman, Lars (2013) In Human Brain Mapping 34(6). p.1386-1398
Abstract
Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60-87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. Results showed good fit of a model positing that individual differences in white matter microstructure are structured according to tracts. A general factor, although accounting for variance in the measures, did not adequately represent the individual differences. This indicates the presence of a substantial amount of tract-specific individual... (More)
Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60-87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. Results showed good fit of a model positing that individual differences in white matter microstructure are structured according to tracts. A general factor, although accounting for variance in the measures, did not adequately represent the individual differences. This indicates the presence of a substantial amount of tract-specific individual differences in white matter microstructure. In addition, individual differences are to a varying degree shared between tracts, indicating that general factors also affect white matter microstructure. Age-related differences in white matter microstructure were present for all tracts. Correlations among tract factors did not generally increase as a function of age, suggesting that aging is not a process with homogenous effects on white matter microstructure across the brain. These findings highlight the need for future research to examine whether relations between white matter microstructure and diverse outcomes are specific or general. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Brain Mapping
volume
34
issue
6
pages
1386 - 1398
publisher
Wiley-Blackwell
external identifiers
  • wos:000317855400012
  • scopus:84876410089
  • pmid:22331619
ISSN
1065-9471
DOI
10.1002/hbm.21518
language
English
LU publication?
yes
id
fa20806d-2487-423b-a255-246a843d477c (old id 2366934)
date added to LUP
2016-04-01 11:13:55
date last changed
2020-12-08 04:29:51
@article{fa20806d-2487-423b-a255-246a843d477c,
  abstract     = {Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60-87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. Results showed good fit of a model positing that individual differences in white matter microstructure are structured according to tracts. A general factor, although accounting for variance in the measures, did not adequately represent the individual differences. This indicates the presence of a substantial amount of tract-specific individual differences in white matter microstructure. In addition, individual differences are to a varying degree shared between tracts, indicating that general factors also affect white matter microstructure. Age-related differences in white matter microstructure were present for all tracts. Correlations among tract factors did not generally increase as a function of age, suggesting that aging is not a process with homogenous effects on white matter microstructure across the brain. These findings highlight the need for future research to examine whether relations between white matter microstructure and diverse outcomes are specific or general. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.},
  author       = {Lövdén, Martin and Laukka, Erika Jonsson and Rieckmann, Anna and Kalpouzos, Grégoria and Li, Tie-Qiang and Jonsson, Tomas and Wahlund, Lars-Olof and Fratiglioni, Laura and Bäckman, Lars},
  issn         = {1065-9471},
  language     = {eng},
  number       = {6},
  pages        = {1386--1398},
  publisher    = {Wiley-Blackwell},
  series       = {Human Brain Mapping},
  title        = {The dimensionality of between-person differences in white matter microstructure in old age.},
  url          = {http://dx.doi.org/10.1002/hbm.21518},
  doi          = {10.1002/hbm.21518},
  volume       = {34},
  year         = {2013},
}