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The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort

Schiff, Jessica E ; Vieira, Carolina L Z ; Garshick, Eric ; Wang, Veronica ; Blomberg, Annelise LU orcid ; Gold, Diane R ; Schwartz, Joel ; Tracy, Samantha M ; Vokonas, Pantel and Koutrakis, Petros (2022) In PLoS ONE 17(7).
Abstract

This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive... (More)

This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive associations between sICAM-1 and sVCAM-1 concentrations and solar and geomagnetic activity parameters: IMF, SSN, and Kp. Additionally, a negative association was observed between fibrinogen and Kp index and a positive association was observed for CRP and SSN. These results demonstrate that solar and geomagnetic activity might be upregulating endothelial activation and inflammation.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, C-Reactive Protein/analysis, Fibrinogen/analysis, Humans, Inflammation/metabolism, Intercellular Adhesion Molecule-1/metabolism, Plant Extracts, Vascular Cell Adhesion Molecule-1/metabolism
in
PLoS ONE
volume
17
issue
7
article number
e0268700
publisher
Public Library of Science (PLoS)
external identifiers
  • scopus:85135071729
  • pmid:35881632
ISSN
1932-6203
DOI
10.1371/journal.pone.0268700
language
English
LU publication?
no
id
fa75662e-321c-4c32-877b-888c0a0c006d
date added to LUP
2025-09-17 10:45:57
date last changed
2025-10-02 06:03:30
@article{fa75662e-321c-4c32-877b-888c0a0c006d,
  abstract     = {{<p>This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive associations between sICAM-1 and sVCAM-1 concentrations and solar and geomagnetic activity parameters: IMF, SSN, and Kp. Additionally, a negative association was observed between fibrinogen and Kp index and a positive association was observed for CRP and SSN. These results demonstrate that solar and geomagnetic activity might be upregulating endothelial activation and inflammation.</p>}},
  author       = {{Schiff, Jessica E and Vieira, Carolina L Z and Garshick, Eric and Wang, Veronica and Blomberg, Annelise and Gold, Diane R and Schwartz, Joel and Tracy, Samantha M and Vokonas, Pantel and Koutrakis, Petros}},
  issn         = {{1932-6203}},
  keywords     = {{Biomarkers; C-Reactive Protein/analysis; Fibrinogen/analysis; Humans; Inflammation/metabolism; Intercellular Adhesion Molecule-1/metabolism; Plant Extracts; Vascular Cell Adhesion Molecule-1/metabolism}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0268700}},
  doi          = {{10.1371/journal.pone.0268700}},
  volume       = {{17}},
  year         = {{2022}},
}