Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Echocardiographic global longitudinal strain is associated with infarct size assessed by cardiac magnetic resonance in acute myocardial infarction

Joseph, Gowsini ; Zaremba, Tomas ; Johansen, Martin Berg ; Ekeloef, Sarah ; Heiberg, Einar LU ; Engblom, Henrik LU ; Jensen, Svend Eggert and Sogaard, Peter (2019) In Echo Research and Practice 6(4). p.81-89
Abstract

The aim of this study was to investigate if there was an association between infarct size (IS) measured by cardiac magnetic resonance (CMR) and echocardiographic global longitudinal strain (GLS) in the early stage of acute myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF). Patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were assessed with CMR and transthoracic echocardiogram within 1 week of hospital admission. Two-dimensional speckle tracking was performed using a semi-automatic algorithm (EchoPac, GE Healthcare). Longitudinal strain curves were generated in a 17-segment model covering the entire left ventricular myocardium. GLS... (More)

The aim of this study was to investigate if there was an association between infarct size (IS) measured by cardiac magnetic resonance (CMR) and echocardiographic global longitudinal strain (GLS) in the early stage of acute myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF). Patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were assessed with CMR and transthoracic echocardiogram within 1 week of hospital admission. Two-dimensional speckle tracking was performed using a semi-automatic algorithm (EchoPac, GE Healthcare). Longitudinal strain curves were generated in a 17-segment model covering the entire left ventricular myocardium. GLS was calculated automatically. LVEF was measured by auto-LVEF in EchoPac. IS was measured by late gadolinium enhancement CMR in short-axis views covering the left ventricle. The study population consisted of 49 patients (age 60.4 ± 9.7 years; 92% male). The study population had preserved echocardiographic LVEF with a mean of 45.8 ± 8.7%. For each percent increase of IS, we found an impairment in GLS by 1.59% (95% CI 0.57–2.61), P = 0.02, after adjustment for sex, age and LVEF. No significant association between IS and echocardiographic LVEF was found: −0.25 (95% CI: −0.61 to 0.11), P = 0.51. At the segmental level, the strongest association between IS and longitudinal strain was found in the apical part of the LV: impairment of 1.69% (95% CI: 1.14–2.23), P < 0.001, for each percent increase in IS. In conclusion, GLS was significantly associated with IS in the early stage of acute myocardial infarction in patients with preserved LVEF, and this association was strongest in the apical part of the LV. No association between IS and LVEF was found.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
2D speckle tracking echocardiography, Acute myocardial infarction, Cardiac magnetic resonance imaging, Global longitudinal strain, Infarct size
in
Echo Research and Practice
volume
6
issue
4
pages
9 pages
publisher
BioScientifica
external identifiers
  • scopus:85072318104
  • pmid:31516721
ISSN
2055-0464
DOI
10.1530/ERP-19-0016
language
English
LU publication?
yes
id
fa8093bb-de19-49fe-90f7-5448424d0cfc
date added to LUP
2019-10-07 14:07:17
date last changed
2024-04-16 21:43:18
@article{fa8093bb-de19-49fe-90f7-5448424d0cfc,
  abstract     = {{<p>The aim of this study was to investigate if there was an association between infarct size (IS) measured by cardiac magnetic resonance (CMR) and echocardiographic global longitudinal strain (GLS) in the early stage of acute myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF). Patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were assessed with CMR and transthoracic echocardiogram within 1 week of hospital admission. Two-dimensional speckle tracking was performed using a semi-automatic algorithm (EchoPac, GE Healthcare). Longitudinal strain curves were generated in a 17-segment model covering the entire left ventricular myocardium. GLS was calculated automatically. LVEF was measured by auto-LVEF in EchoPac. IS was measured by late gadolinium enhancement CMR in short-axis views covering the left ventricle. The study population consisted of 49 patients (age 60.4 ± 9.7 years; 92% male). The study population had preserved echocardiographic LVEF with a mean of 45.8 ± 8.7%. For each percent increase of IS, we found an impairment in GLS by 1.59% (95% CI 0.57–2.61), P = 0.02, after adjustment for sex, age and LVEF. No significant association between IS and echocardiographic LVEF was found: −0.25 (95% CI: −0.61 to 0.11), P = 0.51. At the segmental level, the strongest association between IS and longitudinal strain was found in the apical part of the LV: impairment of 1.69% (95% CI: 1.14–2.23), P &lt; 0.001, for each percent increase in IS. In conclusion, GLS was significantly associated with IS in the early stage of acute myocardial infarction in patients with preserved LVEF, and this association was strongest in the apical part of the LV. No association between IS and LVEF was found.</p>}},
  author       = {{Joseph, Gowsini and Zaremba, Tomas and Johansen, Martin Berg and Ekeloef, Sarah and Heiberg, Einar and Engblom, Henrik and Jensen, Svend Eggert and Sogaard, Peter}},
  issn         = {{2055-0464}},
  keywords     = {{2D speckle tracking echocardiography; Acute myocardial infarction; Cardiac magnetic resonance imaging; Global longitudinal strain; Infarct size}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{81--89}},
  publisher    = {{BioScientifica}},
  series       = {{Echo Research and Practice}},
  title        = {{Echocardiographic global longitudinal strain is associated with infarct size assessed by cardiac magnetic resonance in acute myocardial infarction}},
  url          = {{http://dx.doi.org/10.1530/ERP-19-0016}},
  doi          = {{10.1530/ERP-19-0016}},
  volume       = {{6}},
  year         = {{2019}},
}