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Endocrine disruptors and testicular function

Lymperi, Stefania and Giwercman, Aleksander LU (2018) In Metabolism: Clinical and Experimental
Abstract

Despite concerns of the scientific community regarding the adverse effects of human exposure to exogenous man-made chemical substances or mixtures that interfere with normal hormonal balance, the so called “endocrine disruptors (EDs)”, their production has been increased during the last few decades. EDs' extensive use has been implicated in the increasing incidence of male reproductive disorders including poor semen quality, testicular malignancies and congenital developmental defects such as hypospadias and cryptorchidism. Several animal studies have demonstrated that exposure to EDs during fetal, neonatal and adult life has deleterious consequences on male reproductive system; however, the evidence on humans remains ambiguous. The... (More)

Despite concerns of the scientific community regarding the adverse effects of human exposure to exogenous man-made chemical substances or mixtures that interfere with normal hormonal balance, the so called “endocrine disruptors (EDs)”, their production has been increased during the last few decades. EDs' extensive use has been implicated in the increasing incidence of male reproductive disorders including poor semen quality, testicular malignancies and congenital developmental defects such as hypospadias and cryptorchidism. Several animal studies have demonstrated that exposure to EDs during fetal, neonatal and adult life has deleterious consequences on male reproductive system; however, the evidence on humans remains ambiguous. The complexity of their mode of action, the differential effect according to the developmental stage that exposure occurs, the latency from exposure and the influence of the genetic background in the manifestation of their toxic effects are all responsible factors for the contradictory outcomes. Furthermore, the heterogeneity in the published human studies has hampered agreement in the field. Interventional studies to establish causality would be desirable, but unfortunately the nature of the field excludes this possibility. Therefore, future studies based on standardized guidelines are necessary, in order to estimate human health risks and implement policies to limit public exposure.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Anogenital distance, Cryptorchidism, Endocrine disruptors, Hypospadias, Male infertility, Testicular cancer, Testicular dysgenesis syndrome
in
Metabolism: Clinical and Experimental
publisher
Elsevier
external identifiers
  • scopus:85046377508
ISSN
0026-0495
DOI
10.1016/j.metabol.2018.03.022
language
English
LU publication?
yes
id
fa932a8a-f00d-47f9-9cf7-18d9c8cb0642
date added to LUP
2018-05-17 14:30:07
date last changed
2018-05-29 10:34:36
@article{fa932a8a-f00d-47f9-9cf7-18d9c8cb0642,
  abstract     = {<p>Despite concerns of the scientific community regarding the adverse effects of human exposure to exogenous man-made chemical substances or mixtures that interfere with normal hormonal balance, the so called “endocrine disruptors (EDs)”, their production has been increased during the last few decades. EDs' extensive use has been implicated in the increasing incidence of male reproductive disorders including poor semen quality, testicular malignancies and congenital developmental defects such as hypospadias and cryptorchidism. Several animal studies have demonstrated that exposure to EDs during fetal, neonatal and adult life has deleterious consequences on male reproductive system; however, the evidence on humans remains ambiguous. The complexity of their mode of action, the differential effect according to the developmental stage that exposure occurs, the latency from exposure and the influence of the genetic background in the manifestation of their toxic effects are all responsible factors for the contradictory outcomes. Furthermore, the heterogeneity in the published human studies has hampered agreement in the field. Interventional studies to establish causality would be desirable, but unfortunately the nature of the field excludes this possibility. Therefore, future studies based on standardized guidelines are necessary, in order to estimate human health risks and implement policies to limit public exposure.</p>},
  author       = {Lymperi, Stefania and Giwercman, Aleksander},
  issn         = {0026-0495},
  keyword      = {Anogenital distance,Cryptorchidism,Endocrine disruptors,Hypospadias,Male infertility,Testicular cancer,Testicular dysgenesis syndrome},
  language     = {eng},
  month        = {01},
  publisher    = {Elsevier},
  series       = {Metabolism: Clinical and Experimental},
  title        = {Endocrine disruptors and testicular function},
  url          = {http://dx.doi.org/10.1016/j.metabol.2018.03.022},
  year         = {2018},
}