A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis
(2021) In European Journal of Nuclear Medicine and Molecular Imaging 48(7). p.2295-2305- Abstract
Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic... (More)
Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926–0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.
(Less)
- author
- organization
- publishing date
- 2021-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- PET, Tau, [F]Flortaucipir, [F]MK6240, [F]RO948
- in
- European Journal of Nuclear Medicine and Molecular Imaging
- volume
- 48
- issue
- 7
- pages
- 11 pages
- publisher
- Springer
- external identifiers
-
- scopus:85106456393
- pmid:34041562
- ISSN
- 1619-7070
- DOI
- 10.1007/s00259-021-05401-4
- language
- English
- LU publication?
- yes
- id
- fac5e56a-9f05-4826-b035-01677632bf29
- date added to LUP
- 2021-06-17 10:54:21
- date last changed
- 2024-09-21 21:41:18
@article{fac5e56a-9f05-4826-b035-01677632bf29, abstract = {{<p>Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [<sup>18</sup>F]flortaucipir (n = 975), [<sup>18</sup>F]RO948 (n = 493), or [<sup>18</sup>F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926–0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.</p>}}, author = {{Leuzy, Antoine and Pascoal, Tharick A. and Strandberg, Olof and Insel, Philip and Smith, Ruben and Mattsson-Carlgren, Niklas and Benedet, Andréa L. and Cho, Hannah and Lyoo, Chul H. and La Joie, Renaud and Rabinovici, Gil D. and Ossenkoppele, Rik and Rosa-Neto, Pedro and Hansson, Oskar}}, issn = {{1619-7070}}, keywords = {{PET; Tau; [F]Flortaucipir; [F]MK6240; [F]RO948}}, language = {{eng}}, number = {{7}}, pages = {{2295--2305}}, publisher = {{Springer}}, series = {{European Journal of Nuclear Medicine and Molecular Imaging}}, title = {{A multicenter comparison of [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis}}, url = {{http://dx.doi.org/10.1007/s00259-021-05401-4}}, doi = {{10.1007/s00259-021-05401-4}}, volume = {{48}}, year = {{2021}}, }