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On estimating intraventricular hemodynamic forces from endocardial dynamics : A comparative study with 4D flow MRI

Pedrizzetti, Gianni; Arvidsson, Per M. LU ; Töger, Johannes LU ; Borgquist, Rasmus LU ; Domenichini, Federico; Arheden, Håkan LU and Heiberg, Einar LU (2017) In Journal of Biomechanics 60. p.203-210
Abstract

Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study,... (More)

Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study, we introduce a simplified model based on first principles of fluid dynamics that allows estimating hemodynamic forces without knowing the velocity field inside the LV. The model is validated with 3D phase-contrast MRI (known as 4D flow MRI) in 15 subjects, (5 healthy and 10 patients) using the endocardial surface reconstructed from the three standard long-axis projections. Results demonstrate that the model provides consistent estimates for the base-apex component (mean correlation coefficient r = 0.77 for instantaneous values and r = 0.88 for root mean square) and good estimates of the inferolateral-anteroseptal component (r = 0.50 and 0.84, respectively). The present method represents a potential integration to the existing ones quantifying endocardial deformation in MRI and echocardiography to add a physics-based estimation of the corresponding hemodynamic forces. These could help the clinician to early detect sub-clinical diseases and differentiate between different cardiac dysfunctional states.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4D flow MRI, Cardiac fluid dynamics, Hemodynamic forces, Intraventricular pressure gradient
in
Journal of Biomechanics
volume
60
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85023612132
  • wos:000408287300027
ISSN
0021-9290
DOI
10.1016/j.jbiomech.2017.06.046
language
English
LU publication?
yes
id
fae824a1-d6d0-412d-a7b3-f0cf657d07e9
date added to LUP
2017-08-22 14:53:09
date last changed
2018-01-07 12:15:45
@article{fae824a1-d6d0-412d-a7b3-f0cf657d07e9,
  abstract     = {<p>Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study, we introduce a simplified model based on first principles of fluid dynamics that allows estimating hemodynamic forces without knowing the velocity field inside the LV. The model is validated with 3D phase-contrast MRI (known as 4D flow MRI) in 15 subjects, (5 healthy and 10 patients) using the endocardial surface reconstructed from the three standard long-axis projections. Results demonstrate that the model provides consistent estimates for the base-apex component (mean correlation coefficient r = 0.77 for instantaneous values and r = 0.88 for root mean square) and good estimates of the inferolateral-anteroseptal component (r = 0.50 and 0.84, respectively). The present method represents a potential integration to the existing ones quantifying endocardial deformation in MRI and echocardiography to add a physics-based estimation of the corresponding hemodynamic forces. These could help the clinician to early detect sub-clinical diseases and differentiate between different cardiac dysfunctional states.</p>},
  author       = {Pedrizzetti, Gianni and Arvidsson, Per M. and Töger, Johannes and Borgquist, Rasmus and Domenichini, Federico and Arheden, Håkan and Heiberg, Einar},
  issn         = {0021-9290},
  keyword      = {4D flow MRI,Cardiac fluid dynamics,Hemodynamic forces,Intraventricular pressure gradient},
  language     = {eng},
  month        = {07},
  pages        = {203--210},
  publisher    = {Elsevier},
  series       = {Journal of Biomechanics},
  title        = {On estimating intraventricular hemodynamic forces from endocardial dynamics : A comparative study with 4D flow MRI},
  url          = {http://dx.doi.org/10.1016/j.jbiomech.2017.06.046},
  volume       = {60},
  year         = {2017},
}