On estimating intraventricular hemodynamic forces from endocardial dynamics : A comparative study with 4D flow MRI
Pedrizzetti, Gianni ; Arvidsson, Per M. LU ; Töger, Johannes LU ; Borgquist, Rasmus LU
; Domenichini, Federico
; Arheden, Håkan
LU
and Heiberg, Einar
LU
(2017)
In Journal of Biomechanics
60.
p.203-210
- Abstract
Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study,... (More)
Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study, we introduce a simplified model based on first principles of fluid dynamics that allows estimating hemodynamic forces without knowing the velocity field inside the LV. The model is validated with 3D phase-contrast MRI (known as 4D flow MRI) in 15 subjects, (5 healthy and 10 patients) using the endocardial surface reconstructed from the three standard long-axis projections. Results demonstrate that the model provides consistent estimates for the base-apex component (mean correlation coefficient r = 0.77 for instantaneous values and r = 0.88 for root mean square) and good estimates of the inferolateral-anteroseptal component (r = 0.50 and 0.84, respectively). The present method represents a potential integration to the existing ones quantifying endocardial deformation in MRI and echocardiography to add a physics-based estimation of the corresponding hemodynamic forces. These could help the clinician to early detect sub-clinical diseases and differentiate between different cardiac dysfunctional states.
(Less)
- author
- Pedrizzetti, Gianni
; Arvidsson, Per M.
LU
; Töger, Johannes
LU
; Borgquist, Rasmus
LU
; Domenichini, Federico
; Arheden, Håkan
LU
and Heiberg, Einar
LU
- organization
- publishing date
- 2017-07-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4D flow MRI, Cardiac fluid dynamics, Hemodynamic forces, Intraventricular pressure gradient
- in
- Journal of Biomechanics
- volume
- 60
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85023612132
- pmid:28711164
- wos:000408287300027
- ISSN
- 0021-9290
- DOI
- 10.1016/j.jbiomech.2017.06.046
- language
- English
- LU publication?
- yes
- id
- fae824a1-d6d0-412d-a7b3-f0cf657d07e9
- date added to LUP
- 2017-08-22 14:53:09
- date last changed
- 2024-06-25 02:36:00
@article{fae824a1-d6d0-412d-a7b3-f0cf657d07e9,
abstract = {{<p>Intraventricular pressure gradients or hemodynamic forces, which are their global measure integrated over the left ventricular volume, have a fundamental importance in ventricular function. They may help revealing a sub-optimal cardiac function that is not evident in terms of tissue motion, which is naturally heterogeneous and variable, and can influence cardiac adaptation. However, hemodynamic forces are not utilized in clinical cardiology due to the unavailability of simple non-invasive measurement tools. Hemodynamic forces depend on the intraventricular flow; nevertheless, most of them are imputable to the dynamics of the endocardial flow boundary and to the exchange of momentum across the mitral and aortic orifices. In this study, we introduce a simplified model based on first principles of fluid dynamics that allows estimating hemodynamic forces without knowing the velocity field inside the LV. The model is validated with 3D phase-contrast MRI (known as 4D flow MRI) in 15 subjects, (5 healthy and 10 patients) using the endocardial surface reconstructed from the three standard long-axis projections. Results demonstrate that the model provides consistent estimates for the base-apex component (mean correlation coefficient r = 0.77 for instantaneous values and r = 0.88 for root mean square) and good estimates of the inferolateral-anteroseptal component (r = 0.50 and 0.84, respectively). The present method represents a potential integration to the existing ones quantifying endocardial deformation in MRI and echocardiography to add a physics-based estimation of the corresponding hemodynamic forces. These could help the clinician to early detect sub-clinical diseases and differentiate between different cardiac dysfunctional states.</p>}},
author = {{Pedrizzetti, Gianni and Arvidsson, Per M. and Töger, Johannes and Borgquist, Rasmus and Domenichini, Federico and Arheden, Håkan and Heiberg, Einar}},
issn = {{0021-9290}},
keywords = {{4D flow MRI; Cardiac fluid dynamics; Hemodynamic forces; Intraventricular pressure gradient}},
language = {{eng}},
month = {{07}},
pages = {{203--210}},
publisher = {{Elsevier}},
series = {{Journal of Biomechanics}},
title = {{On estimating intraventricular hemodynamic forces from endocardial dynamics : A comparative study with 4D flow MRI}},
url = {{http://dx.doi.org/10.1016/j.jbiomech.2017.06.046}},
doi = {{10.1016/j.jbiomech.2017.06.046}},
volume = {{60}},
year = {{2017}},
}