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Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients

Wang, Xiao LU ; Sundquist, Kristina LU ; Hedelius, Anna LU ; Palmér, Karolina LU ; Memon, Ashfaque A. LU and Sundquist, Jan LU (2017) In BMC Psychiatry 17(1).
Abstract

Background: The primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim was to examine the association between telomere length and baseline characteristics in the patients. The third aim was to examine the potential effects of the 8-week treatments (mindfulness-based group therapy or treatment as usual, i.e. mostly cognitive-based therapy) on telomere length, and to examine whether there was a difference in the potential effect on telomere length between the two groups. Methods: A total of 501 individuals including 181 patients (aged 20-64 years), with depression, anxiety and stress and... (More)

Background: The primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim was to examine the association between telomere length and baseline characteristics in the patients. The third aim was to examine the potential effects of the 8-week treatments (mindfulness-based group therapy or treatment as usual, i.e. mostly cognitive-based therapy) on telomere length, and to examine whether there was a difference in the potential effect on telomere length between the two groups. Methods: A total of 501 individuals including 181 patients (aged 20-64 years), with depression, anxiety and stress and adjustment disorders, and 320 healthy controls (aged 19-70 years) were recruited in the study. Patient data were collected from a randomized controlled trial comparing mindfulness-based group therapy with treatment as usual. We isolated genomic DNA from blood samples, collected at baseline and after the 8-week follow-up. Telomere length was measured by quantitative real-time (qRT)-PCR. Results: Telomere length was significantly shorter in the patients (mean = 0.77 ± 0.12,), compared to the controls (mean = 0.81 ± 0.14) (p = 0.006). The difference in telomere length remained significant after controlling for age and sex. Old age, male sex and being overweight were associated with shorter telomere length. There was no significant difference in telomere length between baseline and at the 8-week follow-up in any of the treatment groups and no difference between the two groups. Conclusion: Our findings confirm that telomere length, as compared with healthy controls, is shortened in patients with depression, anxiety and stress and adjustment disorders. In both groups (mindfulness-based group therapy or treatment as usual), the telomere length remained unchanged after the 8-week treatment/follow-up and there was no difference between the two groups. Trial registration: (ClinicalTrials.gov ID: NCT01476371 ) Registered November 11, 2011.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anxiety, Depression, Stress and adjustment disorders, Telomere length
in
BMC Psychiatry
volume
17
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85018572787
  • wos:000405441700001
ISSN
1471-244X
DOI
10.1186/s12888-017-1308-0
language
English
LU publication?
yes
id
fb0d7990-a252-4aae-a057-15d05a1007a6
date added to LUP
2017-06-08 13:44:54
date last changed
2018-01-07 12:06:38
@article{fb0d7990-a252-4aae-a057-15d05a1007a6,
  abstract     = {<p>Background: The primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim was to examine the association between telomere length and baseline characteristics in the patients. The third aim was to examine the potential effects of the 8-week treatments (mindfulness-based group therapy or treatment as usual, i.e. mostly cognitive-based therapy) on telomere length, and to examine whether there was a difference in the potential effect on telomere length between the two groups. Methods: A total of 501 individuals including 181 patients (aged 20-64 years), with depression, anxiety and stress and adjustment disorders, and 320 healthy controls (aged 19-70 years) were recruited in the study. Patient data were collected from a randomized controlled trial comparing mindfulness-based group therapy with treatment as usual. We isolated genomic DNA from blood samples, collected at baseline and after the 8-week follow-up. Telomere length was measured by quantitative real-time (qRT)-PCR. Results: Telomere length was significantly shorter in the patients (mean = 0.77 ± 0.12,), compared to the controls (mean = 0.81 ± 0.14) (p = 0.006). The difference in telomere length remained significant after controlling for age and sex. Old age, male sex and being overweight were associated with shorter telomere length. There was no significant difference in telomere length between baseline and at the 8-week follow-up in any of the treatment groups and no difference between the two groups. Conclusion: Our findings confirm that telomere length, as compared with healthy controls, is shortened in patients with depression, anxiety and stress and adjustment disorders. In both groups (mindfulness-based group therapy or treatment as usual), the telomere length remained unchanged after the 8-week treatment/follow-up and there was no difference between the two groups. Trial registration: (ClinicalTrials.gov ID: NCT01476371 ) Registered November 11, 2011.</p>},
  articleno    = {148},
  author       = {Wang, Xiao and Sundquist, Kristina and Hedelius, Anna and Palmér, Karolina and Memon, Ashfaque A. and Sundquist, Jan},
  issn         = {1471-244X},
  keyword      = {Anxiety,Depression,Stress and adjustment disorders,Telomere length},
  language     = {eng},
  month        = {04},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Psychiatry},
  title        = {Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients},
  url          = {http://dx.doi.org/10.1186/s12888-017-1308-0},
  volume       = {17},
  year         = {2017},
}