A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth pattern.
(2011) In Cancer Dec. p.1279-1287- Abstract
- BACKGROUND:: In soft tissue sarcoma, better distinction of high-risk and low-risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade. METHODS:: Whole-tumor sections from 239 soft tissue sarcomas of the extremities were reviewed for the following prognostic factors: size, vascular invasion, necrosis, and growth pattern. A new prognostic model, referred to as SING (Size, Invasion, Necrosis, Growth), was established and compared with other clinically applied systems. RESULTS:: Size, vascular invasion, necrosis, and peripheral tumor growth pattern... (More)
- BACKGROUND:: In soft tissue sarcoma, better distinction of high-risk and low-risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade. METHODS:: Whole-tumor sections from 239 soft tissue sarcomas of the extremities were reviewed for the following prognostic factors: size, vascular invasion, necrosis, and growth pattern. A new prognostic model, referred to as SING (Size, Invasion, Necrosis, Growth), was established and compared with other clinically applied systems. RESULTS:: Size, vascular invasion, necrosis, and peripheral tumor growth pattern provided independent prognostic information with hazard ratios of 2.2-2.6 for development of metastases in multivariate analysis. When these factors were combined into the prognostic model SING, high risk of metastasis was predicted with a sensitivity of 74% and a specificity of 85%. Moreover, the prognostic performance of SING compared favorably with other widely used systems. CONCLUSIONS:: SING represents a promising prognostic model, and vascular invasion and tumor growth pattern should be considered in soft tissue sarcoma prognostication. Cancer 2010. © 2010 American Cancer Society. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1732146
- author
- Carneiro, Ana LU ; Bendahl, Pär-Ola LU ; Engellau, Jacob LU ; Domanski, Henryk LU ; Fletcher, Christopher D ; Rissler, Pehr ; Rydholm, Anders LU and Nilbert, Mef LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer
- volume
- Dec
- pages
- 1279 - 1287
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000288349300021
- pmid:21061335
- scopus:79952394852
- pmid:21381015
- ISSN
- 1097-0142
- DOI
- 10.1002/cncr.25621
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Department of Orthopaedics (Lund) (013028000), Pathology, (Lund) (013030000)
- id
- fb2cf8dc-a93a-4130-b5e0-f5dcd3e47b2d (old id 1732146)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21061335?dopt=Abstract
- date added to LUP
- 2016-04-04 07:08:04
- date last changed
- 2022-03-30 21:51:45
@article{fb2cf8dc-a93a-4130-b5e0-f5dcd3e47b2d, abstract = {{BACKGROUND:: In soft tissue sarcoma, better distinction of high-risk and low-risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high-risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade. METHODS:: Whole-tumor sections from 239 soft tissue sarcomas of the extremities were reviewed for the following prognostic factors: size, vascular invasion, necrosis, and growth pattern. A new prognostic model, referred to as SING (Size, Invasion, Necrosis, Growth), was established and compared with other clinically applied systems. RESULTS:: Size, vascular invasion, necrosis, and peripheral tumor growth pattern provided independent prognostic information with hazard ratios of 2.2-2.6 for development of metastases in multivariate analysis. When these factors were combined into the prognostic model SING, high risk of metastasis was predicted with a sensitivity of 74% and a specificity of 85%. Moreover, the prognostic performance of SING compared favorably with other widely used systems. CONCLUSIONS:: SING represents a promising prognostic model, and vascular invasion and tumor growth pattern should be considered in soft tissue sarcoma prognostication. Cancer 2010. © 2010 American Cancer Society.}}, author = {{Carneiro, Ana and Bendahl, Pär-Ola and Engellau, Jacob and Domanski, Henryk and Fletcher, Christopher D and Rissler, Pehr and Rydholm, Anders and Nilbert, Mef}}, issn = {{1097-0142}}, language = {{eng}}, pages = {{1279--1287}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Cancer}}, title = {{A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth pattern.}}, url = {{http://dx.doi.org/10.1002/cncr.25621}}, doi = {{10.1002/cncr.25621}}, volume = {{Dec}}, year = {{2011}}, }