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Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia : A population-based study from the Swedish AML registry

Lj Lazarevic, Vladimir LU ; Rosso, Aldana LU ; Juliusson, Gunnar LU ; Antunovic, Petar; Derolf, Åsa Rangert; Deneberg, Stefan; Möllgård, Lars; Uggla, Bertil; Wennström, Lovisa and Wahlin, Anders, et al. (2017) In European Journal of Haematology
Abstract

OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.

RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated... (More)

OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.

RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).

CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

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European Journal of Haematology
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Wiley-Blackwell
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  • scopus:85014778341
  • wos:000399882100009
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1600-0609
DOI
10.1111/ejh.12861
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English
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fb73da16-5cf8-417b-9b9d-473773f33563
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2017-03-21 21:28:37
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2017-09-18 11:33:38
@article{fb73da16-5cf8-417b-9b9d-473773f33563,
  abstract     = {<p>OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.</p><p>RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at &gt;60 years; P&lt;.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).</p><p>CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.</p>},
  author       = {Lj Lazarevic, Vladimir and Rosso, Aldana and Juliusson, Gunnar and Antunovic, Petar and Derolf, Åsa Rangert and Deneberg, Stefan and Möllgård, Lars and Uggla, Bertil and Wennström, Lovisa and Wahlin, Anders and Höglund, Martin and Lehmann, Sören and Johansson, Bertil},
  issn         = {1600-0609},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {02},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia : A population-based study from the Swedish AML registry},
  url          = {http://dx.doi.org/10.1111/ejh.12861},
  year         = {2017},
}