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Sorting red blood cells by their dynamical properties

Henry, Ewan; Holm, S. H. LU ; Zhang, Z.; Beech, J. P. LU ; Tegenfeldt, J. O. LU ; Fedosov, Dmitry A. and Gompper, Gerhard (2016) 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 p.786-787
Abstract

A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-cellular fluid. We find that the viscosity contrast and associated cell dynamics clearly determine RBC trajectories through DLD devices. Simulation results compare well to experiments and provide new insights into the physical mechanisms which govern the sorting of non-spherical and deformable cells in DLD devices.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cell dynamics, Cell sorting, Deterministic lateral displacement, Red blood cell
in
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
external identifiers
  • scopus:85014156442
ISBN
9780979806490
language
English
LU publication?
yes
id
fbc67599-9dfc-465f-b7e3-0621c943043c
date added to LUP
2017-03-16 09:55:22
date last changed
2017-03-20 09:48:08
@inproceedings{fbc67599-9dfc-465f-b7e3-0621c943043c,
  abstract     = {<p>A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-cellular fluid. We find that the viscosity contrast and associated cell dynamics clearly determine RBC trajectories through DLD devices. Simulation results compare well to experiments and provide new insights into the physical mechanisms which govern the sorting of non-spherical and deformable cells in DLD devices.</p>},
  author       = {Henry, Ewan and Holm, S. H. and Zhang, Z. and Beech, J. P. and Tegenfeldt, J. O. and Fedosov, Dmitry A. and Gompper, Gerhard},
  booktitle    = {20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016},
  isbn         = {9780979806490},
  keyword      = {Cell dynamics,Cell sorting,Deterministic lateral displacement,Red blood cell},
  language     = {eng},
  pages        = {786--787},
  publisher    = {Chemical and Biological Microsystems Society},
  title        = {Sorting red blood cells by their dynamical properties},
  year         = {2016},
}