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Abnormal glucose tolerance and lung function in children with cystic fibrosis. Comparing oral glucose tolerance test and continuous glucose monitoring

Elidottir, Helga LU orcid ; Diemer, Stefanie LU ; Eklund, Erik LU and Hansen, C R LU (2021) In Journal of Cystic Fibrosis 20(5). p.779-784
Abstract

BACKGROUND: Cystic fibrosis (CF) related diabetes (CFRD) is a common complication of CF. CFRD is associated with declining lung function even before its onset. Regular screening for CFRD using oral glucose tolerance test (OGTT) is recommended. Additionally, continuous glucose monitoring (CGM) has surfaced as a possible surveillance method, but evidence for its use and concordance with OGTT has not been established.

METHODS: Children were prospectively recruited at CF center Lund to undergo both intermittent scan CGM (isCGM) and OGTT. Lung function was evaluated by spirometry and multiple breath washout. Demographic and clinical data were collected from the Swedish national CF registry.

RESULTS: 32 patients participated in... (More)

BACKGROUND: Cystic fibrosis (CF) related diabetes (CFRD) is a common complication of CF. CFRD is associated with declining lung function even before its onset. Regular screening for CFRD using oral glucose tolerance test (OGTT) is recommended. Additionally, continuous glucose monitoring (CGM) has surfaced as a possible surveillance method, but evidence for its use and concordance with OGTT has not been established.

METHODS: Children were prospectively recruited at CF center Lund to undergo both intermittent scan CGM (isCGM) and OGTT. Lung function was evaluated by spirometry and multiple breath washout. Demographic and clinical data were collected from the Swedish national CF registry.

RESULTS: 32 patients participated in the study, yielding 28 pairs of isCGMs and OGTTs. The OGTTs showed that two patients met the criteria of CFRD, seven had impaired glucose tolerance (IGT) and indeterminate glycemia (INDET) was found in eleven cases. The isCGM percent of measurements >8mmol/L and the number of peaks per day >11 mmol/L have correlations with intermediate OGTT glucose time points, but not the 2hour glucose value. Patients with abnormal glucose tolerance (AGT) had lower lung function than those with normal glucose tolerance demonstrated by both FEV1% predicted and lung clearance index (LCI).

CONCLUSION: Correlations can be found between isCGM and OGTT in regards to the latter's intermediate time points. LCI demonstrates as well as FEV1% of predicted, worse lung function in children and adolescents with abnormal glucose tolerance in CF.

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; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cystic Fibrosis
volume
20
issue
5
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85099608818
  • pmid:33478894
ISSN
1873-5010
DOI
10.1016/j.jcf.2021.01.002
language
English
LU publication?
yes
id
fbf989da-be79-4e7b-b1b2-f3f898b152f0
date added to LUP
2021-05-27 10:10:15
date last changed
2024-06-15 11:34:22
@article{fbf989da-be79-4e7b-b1b2-f3f898b152f0,
  abstract     = {{<p>BACKGROUND: Cystic fibrosis (CF) related diabetes (CFRD) is a common complication of CF. CFRD is associated with declining lung function even before its onset. Regular screening for CFRD using oral glucose tolerance test (OGTT) is recommended. Additionally, continuous glucose monitoring (CGM) has surfaced as a possible surveillance method, but evidence for its use and concordance with OGTT has not been established.</p><p>METHODS: Children were prospectively recruited at CF center Lund to undergo both intermittent scan CGM (isCGM) and OGTT. Lung function was evaluated by spirometry and multiple breath washout. Demographic and clinical data were collected from the Swedish national CF registry.</p><p>RESULTS: 32 patients participated in the study, yielding 28 pairs of isCGMs and OGTTs. The OGTTs showed that two patients met the criteria of CFRD, seven had impaired glucose tolerance (IGT) and indeterminate glycemia (INDET) was found in eleven cases. The isCGM percent of measurements &gt;8mmol/L and the number of peaks per day &gt;11 mmol/L have correlations with intermediate OGTT glucose time points, but not the 2hour glucose value. Patients with abnormal glucose tolerance (AGT) had lower lung function than those with normal glucose tolerance demonstrated by both FEV1% predicted and lung clearance index (LCI).</p><p>CONCLUSION: Correlations can be found between isCGM and OGTT in regards to the latter's intermediate time points. LCI demonstrates as well as FEV1% of predicted, worse lung function in children and adolescents with abnormal glucose tolerance in CF.</p>}},
  author       = {{Elidottir, Helga and Diemer, Stefanie and Eklund, Erik and Hansen, C R}},
  issn         = {{1873-5010}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{5}},
  pages        = {{779--784}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Cystic Fibrosis}},
  title        = {{Abnormal glucose tolerance and lung function in children with cystic fibrosis. Comparing oral glucose tolerance test and continuous glucose monitoring}},
  url          = {{http://dx.doi.org/10.1016/j.jcf.2021.01.002}},
  doi          = {{10.1016/j.jcf.2021.01.002}},
  volume       = {{20}},
  year         = {{2021}},
}