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Nutritional modulation of AMPK-impact upon metabolic-inflammation

Lyons, Claire L. LU and Roche, Helen M. (2018) In International Journal of Molecular Sciences 19(10).
Abstract

Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation.... (More)

Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AMPK, Dietary fatty acids, IL-1β, Metabolic-inflammation, NLRP3, Nutrigenomics, Nutrition
in
International Journal of Molecular Sciences
volume
19
issue
10
article number
3092
publisher
MDPI AG
external identifiers
  • scopus:85055564428
  • pmid:30304866
ISSN
1661-6596
DOI
10.3390/ijms19103092
language
English
LU publication?
yes
id
fc3496fa-2a02-4f68-843f-7a2e9fd8913d
date added to LUP
2018-11-15 14:40:38
date last changed
2024-03-02 11:54:41
@article{fc3496fa-2a02-4f68-843f-7a2e9fd8913d,
  abstract     = {{<p>Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.</p>}},
  author       = {{Lyons, Claire L. and Roche, Helen M.}},
  issn         = {{1661-6596}},
  keywords     = {{AMPK; Dietary fatty acids; IL-1β; Metabolic-inflammation; NLRP3; Nutrigenomics; Nutrition}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Nutritional modulation of AMPK-impact upon metabolic-inflammation}},
  url          = {{http://dx.doi.org/10.3390/ijms19103092}},
  doi          = {{10.3390/ijms19103092}},
  volume       = {{19}},
  year         = {{2018}},
}