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Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.

Svensson, Daniel LU ; Nebel, Daniel LU and Nilsson, Bengt-Olof LU orcid (2016) In Inflammation Research 65(1). p.25-32
Abstract
The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple... (More)
The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammation Research
volume
65
issue
1
pages
25 - 32
publisher
Birkhäuser Verlag
external identifiers
  • pmid:26433491
  • wos:000367918300003
  • scopus:84952990075
  • pmid:26433491
ISSN
1420-908X
DOI
10.1007/s00011-015-0884-z
project
Vitamin D and estrogen receptor signaling
language
English
LU publication?
yes
id
fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f (old id 8158966)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26433491?dopt=Abstract
date added to LUP
2016-04-01 09:47:33
date last changed
2022-04-27 07:33:52
@article{fc5ee0f1-f18d-4bef-9fa9-e0f502763b5f,
  abstract     = {{The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.}},
  author       = {{Svensson, Daniel and Nebel, Daniel and Nilsson, Bengt-Olof}},
  issn         = {{1420-908X}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{25--32}},
  publisher    = {{Birkhäuser Verlag}},
  series       = {{Inflammation Research}},
  title        = {{Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.}},
  url          = {{https://lup.lub.lu.se/search/files/1246091/8869675.pdf}},
  doi          = {{10.1007/s00011-015-0884-z}},
  volume       = {{65}},
  year         = {{2016}},
}