Isotropic diffusion weighting in PGSE NMR by magic-angle spinning of the q-vector.
(2013) In Journal of Magnetic Resonance 226. p.13-18- Abstract
- When PGSE NMR is applied to water in microheterogeneous materials such as liquid crystals, foodstuffs, porous rocks, and biological tissues, the signal attenuation is often multi-exponential, indicating the presence of pores having a range of sizes or anisotropic domains having a spread of orientations. Here we modify the standard PGSE experiment by introducing low-amplitude harmonically modulated gradients, which effectively make the q-vector perform magic-angle spinning (MAS) about an axis fixed in the laboratory frame. With this new technique, denoted q-MAS PGSE, the signal attenuation depends on the isotropic average of the local diffusion tensor. The capability of q-MAS PGSE to distinguish between pore size and domain orientation... (More)
- When PGSE NMR is applied to water in microheterogeneous materials such as liquid crystals, foodstuffs, porous rocks, and biological tissues, the signal attenuation is often multi-exponential, indicating the presence of pores having a range of sizes or anisotropic domains having a spread of orientations. Here we modify the standard PGSE experiment by introducing low-amplitude harmonically modulated gradients, which effectively make the q-vector perform magic-angle spinning (MAS) about an axis fixed in the laboratory frame. With this new technique, denoted q-MAS PGSE, the signal attenuation depends on the isotropic average of the local diffusion tensor. The capability of q-MAS PGSE to distinguish between pore size and domain orientation dispersion is demonstrated by experiments on a yeast cell suspension and a polydomain anisotropic liquid crystal. In the latter case, the broad distribution of apparent diffusivities observed with PGSE is narrowed to its isotropic average with q-MAS PGSE in a manner that is analogous to the narrowing of chemical shift anisotropy powder patterns using magic-angle sample spinning in solid-state NMR. The new q-MAS PGSE technique could be useful for resolving size/orientation ambiguities in the interpretation of PGSE data from, e.g., water confined within the axons of human brain tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3218528
- author
- Eriksson, Stefanie LU ; Lasic, Samo LU and Topgaard, Daniel LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Magnetic Resonance
- volume
- 226
- pages
- 13 - 18
- publisher
- Academic Press
- external identifiers
-
- wos:000314190700002
- pmid:23178533
- scopus:84869888296
- pmid:23178533
- ISSN
- 1096-0856
- DOI
- 10.1016/j.jmr.2012.10.015
- project
- Development of Novel Diffusion NMR Methods - Preclinical Applications in Colloidal Model Systems
- language
- English
- LU publication?
- yes
- id
- fc7477f3-203a-469f-b1fb-86d53099cd5c (old id 3218528)
- date added to LUP
- 2016-04-01 14:04:09
- date last changed
- 2022-04-22 01:11:51
@article{fc7477f3-203a-469f-b1fb-86d53099cd5c,
abstract = {{When PGSE NMR is applied to water in microheterogeneous materials such as liquid crystals, foodstuffs, porous rocks, and biological tissues, the signal attenuation is often multi-exponential, indicating the presence of pores having a range of sizes or anisotropic domains having a spread of orientations. Here we modify the standard PGSE experiment by introducing low-amplitude harmonically modulated gradients, which effectively make the q-vector perform magic-angle spinning (MAS) about an axis fixed in the laboratory frame. With this new technique, denoted q-MAS PGSE, the signal attenuation depends on the isotropic average of the local diffusion tensor. The capability of q-MAS PGSE to distinguish between pore size and domain orientation dispersion is demonstrated by experiments on a yeast cell suspension and a polydomain anisotropic liquid crystal. In the latter case, the broad distribution of apparent diffusivities observed with PGSE is narrowed to its isotropic average with q-MAS PGSE in a manner that is analogous to the narrowing of chemical shift anisotropy powder patterns using magic-angle sample spinning in solid-state NMR. The new q-MAS PGSE technique could be useful for resolving size/orientation ambiguities in the interpretation of PGSE data from, e.g., water confined within the axons of human brain tissue.}},
author = {{Eriksson, Stefanie and Lasic, Samo and Topgaard, Daniel}},
issn = {{1096-0856}},
language = {{eng}},
pages = {{13--18}},
publisher = {{Academic Press}},
series = {{Journal of Magnetic Resonance}},
title = {{Isotropic diffusion weighting in PGSE NMR by magic-angle spinning of the q-vector.}},
url = {{http://dx.doi.org/10.1016/j.jmr.2012.10.015}},
doi = {{10.1016/j.jmr.2012.10.015}},
volume = {{226}},
year = {{2013}},
}