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Incidence trends and risk factors of carcinoid tumors : a nationwide epidemiologic study from Sweden

Hemminki, K LU and Li, Xinjun LU (2001) In Cancer 92(8). p.10-2204
Abstract

BACKGROUND: Carcinoids are rare indolent neuroendocrine tumors, mainly located in bowel, stomach, and lung. Their etiology is virtually unknown although a family history is a minor cause.

METHODS: Site specific incidence trends and several risk factors of carcinoid tumors were studied based on the nationwide Swedish Family-Cancer Database of 10.2 million individuals and their more than 1 million tumors. Data on a total of 5184 carcinoid tumors were retrieved from the Cancer Registry covering years 1958-1998.

RESULTS: The overall age-adjusted incidence rates were 2.0 for men and 2.4/100,000 for women in 1983-1998. Appendix was the main site for women whereas small intestine was the main site for men. The incidence of all... (More)

BACKGROUND: Carcinoids are rare indolent neuroendocrine tumors, mainly located in bowel, stomach, and lung. Their etiology is virtually unknown although a family history is a minor cause.

METHODS: Site specific incidence trends and several risk factors of carcinoid tumors were studied based on the nationwide Swedish Family-Cancer Database of 10.2 million individuals and their more than 1 million tumors. Data on a total of 5184 carcinoid tumors were retrieved from the Cancer Registry covering years 1958-1998.

RESULTS: The overall age-adjusted incidence rates were 2.0 for men and 2.4/100,000 for women in 1983-1998. Appendix was the main site for women whereas small intestine was the main site for men. The incidence of all carcinoids, including those at the main sites increased during the follow-up period but appeared to plateau in the middle of the 1980s. Appendiceal carcinoids showed an unusually early onset with a maximum incidence at age 15-19 years for women and 20-29 years for men. Among women, parity was not related to the age specific incidence of carcinoid tumors. A Poisson regression analysis showed that family history of carcinoids in first-degree relatives (relative risk, 3.6), well educated social background (relative risk for professionals, 2.8), and birth in large cities were risk factors.

CONCLUSIONS: The data suggest that the increase in carcinoid tumors may be largely ascribed to the application of advanced medical viewing techniques that detect asymptomatic tumors. However, the difference in incidence between men and women in appendiceal tumor may be real and independent of parity.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Carcinoid Tumor/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Poisson Distribution, Registries, Risk Factors, Sweden/epidemiology
in
Cancer
volume
92
issue
8
pages
7 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:0035886412
ISSN
0008-543X
DOI
10.1002/1097-0142(20011015)92:8<2204::AID-CNCR1564>3.0.CO;2-R
language
English
LU publication?
no
id
fc78cbf8-7cb3-4674-89b8-804f2b5c98af
date added to LUP
2019-01-30 12:13:47
date last changed
2019-05-19 05:06:00
@article{fc78cbf8-7cb3-4674-89b8-804f2b5c98af,
  abstract     = {<p>BACKGROUND: Carcinoids are rare indolent neuroendocrine tumors, mainly located in bowel, stomach, and lung. Their etiology is virtually unknown although a family history is a minor cause.</p><p>METHODS: Site specific incidence trends and several risk factors of carcinoid tumors were studied based on the nationwide Swedish Family-Cancer Database of 10.2 million individuals and their more than 1 million tumors. Data on a total of 5184 carcinoid tumors were retrieved from the Cancer Registry covering years 1958-1998.</p><p>RESULTS: The overall age-adjusted incidence rates were 2.0 for men and 2.4/100,000 for women in 1983-1998. Appendix was the main site for women whereas small intestine was the main site for men. The incidence of all carcinoids, including those at the main sites increased during the follow-up period but appeared to plateau in the middle of the 1980s. Appendiceal carcinoids showed an unusually early onset with a maximum incidence at age 15-19 years for women and 20-29 years for men. Among women, parity was not related to the age specific incidence of carcinoid tumors. A Poisson regression analysis showed that family history of carcinoids in first-degree relatives (relative risk, 3.6), well educated social background (relative risk for professionals, 2.8), and birth in large cities were risk factors.</p><p>CONCLUSIONS: The data suggest that the increase in carcinoid tumors may be largely ascribed to the application of advanced medical viewing techniques that detect asymptomatic tumors. However, the difference in incidence between men and women in appendiceal tumor may be real and independent of parity.</p>},
  author       = {Hemminki, K and Li, Xinjun},
  issn         = {0008-543X},
  keyword      = {Adolescent,Adult,Carcinoid Tumor/epidemiology,Female,Humans,Incidence,Male,Middle Aged,Poisson Distribution,Registries,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  month        = {10},
  number       = {8},
  pages        = {10--2204},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Incidence trends and risk factors of carcinoid tumors : a nationwide epidemiologic study from Sweden},
  url          = {http://dx.doi.org/10.1002/1097-0142(20011015)92:8<2204::AID-CNCR1564>3.0.CO;2-R},
  volume       = {92},
  year         = {2001},
}