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Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes

Westhrin, Marita; Moen, Siv Helen; Kristensen, Ida Bruun; Buene, Glenn; Mylin, Anne Kærsgaard; Turesson, Ingemar LU ; Abildgaard, Niels; Waage, Anders and Standal, Therese (2018) In Biomarker research 6(1).
Abstract

Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipocyte, Chemerin, Multiple myeloma, Stromal cell
in
Biomarker research
volume
6
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85062926743
ISSN
2050-7771
DOI
10.1186/s40364-018-0134-y
language
English
LU publication?
yes
id
fcb51ec9-a620-4ac8-a935-c57eb0d51fe8
date added to LUP
2019-04-01 10:09:39
date last changed
2019-04-23 04:47:54
@article{fcb51ec9-a620-4ac8-a935-c57eb0d51fe8,
  abstract     = {<p>Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.</p>},
  articleno    = {21},
  author       = {Westhrin, Marita and Moen, Siv Helen and Kristensen, Ida Bruun and Buene, Glenn and Mylin, Anne Kærsgaard and Turesson, Ingemar and Abildgaard, Niels and Waage, Anders and Standal, Therese},
  issn         = {2050-7771},
  keyword      = {Adipocyte,Chemerin,Multiple myeloma,Stromal cell},
  language     = {eng},
  month        = {06},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Biomarker research},
  title        = {Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes},
  url          = {http://dx.doi.org/10.1186/s40364-018-0134-y},
  volume       = {6},
  year         = {2018},
}