Induction immunosuppression strategies and long-term outcomes after heart transplantation
Nozohoor, Shahab LU ; Stehlik, Josef ; Lund, Lars H. ; Ansari, David LU ; Andersson, Bodil LU
and Nilsson, Johan
LU
(2020)
In Clinical Transplantation
34(7).
- Abstract
Although the use of induction therapy has reduced the risk of acute rejection after heart transplantation, its use may be associated with other adverse outcomes. We aimed to examine the effect of no induction (NoInd), induction with basiliximab (BAS), or induction with antithymocyte globulin (ATG) on outcome after heart transplantation. We analyzed data from the International Society for Heart and Lung Transplantation (ISHLT) registry for adult heart transplants performed between 2000 and 2013. The primary outcome was cumulative all-cause mortality, and the secondary outcome was cause-specific death. We identified 27 369 transplants whose recipients received NoInd (n = 15 688), ATG (n = 6830), or BAS (n = 4851). Over a median follow-up... (More)
Although the use of induction therapy has reduced the risk of acute rejection after heart transplantation, its use may be associated with other adverse outcomes. We aimed to examine the effect of no induction (NoInd), induction with basiliximab (BAS), or induction with antithymocyte globulin (ATG) on outcome after heart transplantation. We analyzed data from the International Society for Heart and Lung Transplantation (ISHLT) registry for adult heart transplants performed between 2000 and 2013. The primary outcome was cumulative all-cause mortality, and the secondary outcome was cause-specific death. We identified 27 369 transplants whose recipients received NoInd (n = 15 688), ATG (n = 6830), or BAS (n = 4851). Over a median follow-up of 1497 days, overall 30-day mortality was 5% and 1-year mortality was 11%. Survival after transplant was similar in patients treated with NoInd compared with ATG. The survival was improved using NoInd compared with BAS (log-rank P =.040), adjustment HR = 1.11 (95% CI, 1.04-1.19). Compared to NoInd, BAS was associated with higher risk of graft failure-related deaths, HR = 1.27 (95% CI, 1.02-1.58), and ATG was associated with higher risk of malignancy-related deaths, HR = 1.18 (95% CI, 1.01-1.39). Survival of patients who received NoInd was similar to ATG and better compared with BAS. Further, the use of ATG may be associated with increased malignancy-related mortality, compared with NoInd.
(Less)
- author
- Nozohoor, Shahab
LU
; Stehlik, Josef
; Lund, Lars H.
; Ansari, David
LU
; Andersson, Bodil
LU
and Nilsson, Johan
LU
- organization
-
- Minimal invasive cardiac surgery in valvular heart disease (research group)
- Bleeding disorders and acute typ-A dissection (research group)
- Less invasive cardiac surgery (research group)
- Artificial Intelligence in CardioThoracic Sciences (AICTS) (research group)
- eSSENCE: The e-Science Collaboration
- Thoracic Surgery
- Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS) (research group)
- Heart and Lung transplantation (research group)
- publishing date
- 2020-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antithymocyte globulin, basiliximab, cardiovascular, graft failure, heart failure, heart transplantation, infection, mortality
- in
- Clinical Transplantation
- volume
- 34
- issue
- 7
- article number
- e13871
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85083957900
- pmid:32271484
- ISSN
- 0902-0063
- DOI
- 10.1111/ctr.13871
- language
- English
- LU publication?
- yes
- id
- fcdda980-c4fa-4cc6-8dd0-29b1100e61dc
- date added to LUP
- 2020-05-28 11:06:08
- date last changed
- 2024-06-13 16:52:54
@article{fcdda980-c4fa-4cc6-8dd0-29b1100e61dc,
abstract = {{<p>Although the use of induction therapy has reduced the risk of acute rejection after heart transplantation, its use may be associated with other adverse outcomes. We aimed to examine the effect of no induction (NoInd), induction with basiliximab (BAS), or induction with antithymocyte globulin (ATG) on outcome after heart transplantation. We analyzed data from the International Society for Heart and Lung Transplantation (ISHLT) registry for adult heart transplants performed between 2000 and 2013. The primary outcome was cumulative all-cause mortality, and the secondary outcome was cause-specific death. We identified 27 369 transplants whose recipients received NoInd (n = 15 688), ATG (n = 6830), or BAS (n = 4851). Over a median follow-up of 1497 days, overall 30-day mortality was 5% and 1-year mortality was 11%. Survival after transplant was similar in patients treated with NoInd compared with ATG. The survival was improved using NoInd compared with BAS (log-rank P =.040), adjustment HR = 1.11 (95% CI, 1.04-1.19). Compared to NoInd, BAS was associated with higher risk of graft failure-related deaths, HR = 1.27 (95% CI, 1.02-1.58), and ATG was associated with higher risk of malignancy-related deaths, HR = 1.18 (95% CI, 1.01-1.39). Survival of patients who received NoInd was similar to ATG and better compared with BAS. Further, the use of ATG may be associated with increased malignancy-related mortality, compared with NoInd.</p>}},
author = {{Nozohoor, Shahab and Stehlik, Josef and Lund, Lars H. and Ansari, David and Andersson, Bodil and Nilsson, Johan}},
issn = {{0902-0063}},
keywords = {{antithymocyte globulin; basiliximab; cardiovascular; graft failure; heart failure; heart transplantation; infection; mortality}},
language = {{eng}},
number = {{7}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Transplantation}},
title = {{Induction immunosuppression strategies and long-term outcomes after heart transplantation}},
url = {{http://dx.doi.org/10.1111/ctr.13871}},
doi = {{10.1111/ctr.13871}},
volume = {{34}},
year = {{2020}},
}