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Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism

Vercruysse, Pauline; Vieau, Didier; Blum, David; Petersén, Åsa LU and Dupuis, Luc (2018) In Frontiers in Molecular Neuroscience 11.
Abstract

Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington’s disease (HD), or cognitive in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Besides the common existence of neuronal loss, NDDs are also associated with metabolic changes such as weight gain, weight loss, loss of fat mass, as well as with altered feeding behavior. Importantly, preclinical research as well as clinical studies have demonstrated that altered energy homeostasis influences disease progression in ALS, AD and HD, suggesting that identification of... (More)

Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington’s disease (HD), or cognitive in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Besides the common existence of neuronal loss, NDDs are also associated with metabolic changes such as weight gain, weight loss, loss of fat mass, as well as with altered feeding behavior. Importantly, preclinical research as well as clinical studies have demonstrated that altered energy homeostasis influences disease progression in ALS, AD and HD, suggesting that identification of the pathways leading to perturbed energy balance might provide valuable therapeutic targets Signals from both the periphery and central inputs are integrated in the hypothalamus, a major hub for the control of energy balance. Recent research identified major hypothalamic changes in multiple NDDs. Here, we review these hypothalamic alterations and seek to identify commonalities and differences in hypothalamic involvement between the different NDDs. These hypothalamic defects could be key in the development of perturbations in energy homeostasis in NDDs and further understanding of the underlying mechanisms might open up new avenues to not only treat weight loss but also to ameliorate overall neurological symptoms.

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organization
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Contribution to journal
publication status
published
subject
keywords
Alzheimer’s disease, Amyotrophic lateral sclerosis, Fronto-temporal dementia, Huntington’s disease, Hypothalamus, Neurodegeneration, Weight loss
in
Frontiers in Molecular Neuroscience
volume
11
external identifiers
  • scopus:85041364142
ISSN
1662-5099
DOI
10.3389/fnmol.2018.00002
language
English
LU publication?
yes
id
fcfc4412-e422-4a51-9b2c-0c21bb14e051
date added to LUP
2018-02-12 11:09:18
date last changed
2018-05-29 10:42:55
@article{fcfc4412-e422-4a51-9b2c-0c21bb14e051,
  abstract     = {<p>Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington’s disease (HD), or cognitive in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Besides the common existence of neuronal loss, NDDs are also associated with metabolic changes such as weight gain, weight loss, loss of fat mass, as well as with altered feeding behavior. Importantly, preclinical research as well as clinical studies have demonstrated that altered energy homeostasis influences disease progression in ALS, AD and HD, suggesting that identification of the pathways leading to perturbed energy balance might provide valuable therapeutic targets Signals from both the periphery and central inputs are integrated in the hypothalamus, a major hub for the control of energy balance. Recent research identified major hypothalamic changes in multiple NDDs. Here, we review these hypothalamic alterations and seek to identify commonalities and differences in hypothalamic involvement between the different NDDs. These hypothalamic defects could be key in the development of perturbations in energy homeostasis in NDDs and further understanding of the underlying mechanisms might open up new avenues to not only treat weight loss but also to ameliorate overall neurological symptoms.</p>},
  articleno    = {2},
  author       = {Vercruysse, Pauline and Vieau, Didier and Blum, David and Petersén, Åsa and Dupuis, Luc},
  issn         = {1662-5099},
  keyword      = {Alzheimer’s disease,Amyotrophic lateral sclerosis,Fronto-temporal dementia,Huntington’s disease,Hypothalamus,Neurodegeneration,Weight loss},
  language     = {eng},
  month        = {01},
  series       = {Frontiers in Molecular Neuroscience},
  title        = {Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism},
  url          = {http://dx.doi.org/10.3389/fnmol.2018.00002},
  volume       = {11},
  year         = {2018},
}