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Disaggregation of gold nanoparticles by Daphnia magna

Mattsson, Karin LU ; Aguilar, Ruben; Torstensson, Oscar; Perry, Diana; Bernfur, Katja LU ; Linse, Sara LU ; Hansson, Lars Anders LU ; Åkerfeldt, Karin S. LU and Cedervall, Tommy LU (2018) In Nanotoxicology 12(8). p.885-900
Abstract

The use of manufactured nanomaterials is rapidly increasing, while our understanding of the consequences of releasing these materials into the environment is still limited and many questions remain, for example, how do nanoparticles affect living organisms in the wild? How do organisms adapt and protect themselves from exposure to foreign materials? How does the environment affect the performance of nanoparticles, including their surface properties? In an effort to address these crucial questions, our main aim has been to probe the effects of aquatic organisms on nanoparticle aggregation. We have, therefore, carried out a systematic study with the purpose to disentangle the effects of the freshwater zooplankter, Daphnia magna, on the... (More)

The use of manufactured nanomaterials is rapidly increasing, while our understanding of the consequences of releasing these materials into the environment is still limited and many questions remain, for example, how do nanoparticles affect living organisms in the wild? How do organisms adapt and protect themselves from exposure to foreign materials? How does the environment affect the performance of nanoparticles, including their surface properties? In an effort to address these crucial questions, our main aim has been to probe the effects of aquatic organisms on nanoparticle aggregation. We have, therefore, carried out a systematic study with the purpose to disentangle the effects of the freshwater zooplankter, Daphnia magna, on the surface properties, stability, and aggregation properties of gold (Au) nanoparticles under different aqueous conditions as well as identified the proteins bound to the nanoparticle surface. We show that Au nanoparticles aggregate in pure tap water, but to a lesser extent in water that either contains Daphnia or has been pre-conditioned with Daphnia. Moreover, we show that proteins generated by Daphnia bind to the Au nanoparticles and create a modified surface that renders them less prone to aggregation. We conclude that the surrounding milieu, as well as the surface properties of the original Au particles, are important factors in determining how the nanoparticles are affected by biological metabolism. In a broader context, our results show how nanoparticles released into a natural ecosystem become chemically and physically altered through the dynamic interactions between particles and organisms, either through biological metabolism or through the interactions with biomolecules excreted by organisms into the environment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aggregation, Daphnia magna, gold, mass spectrometry, nanoparticles, protein corona
in
Nanotoxicology
volume
12
issue
8
pages
885 - 900
publisher
Informa Healthcare
external identifiers
  • scopus:85050978325
ISSN
1743-5390
DOI
10.1080/17435390.2018.1485982
language
English
LU publication?
yes
id
fd22d767-949b-4c46-88d9-ef005ab3d52b
date added to LUP
2018-09-26 15:30:56
date last changed
2019-02-20 11:27:48
@article{fd22d767-949b-4c46-88d9-ef005ab3d52b,
  abstract     = {<p>The use of manufactured nanomaterials is rapidly increasing, while our understanding of the consequences of releasing these materials into the environment is still limited and many questions remain, for example, how do nanoparticles affect living organisms in the wild? How do organisms adapt and protect themselves from exposure to foreign materials? How does the environment affect the performance of nanoparticles, including their surface properties? In an effort to address these crucial questions, our main aim has been to probe the effects of aquatic organisms on nanoparticle aggregation. We have, therefore, carried out a systematic study with the purpose to disentangle the effects of the freshwater zooplankter, Daphnia magna, on the surface properties, stability, and aggregation properties of gold (Au) nanoparticles under different aqueous conditions as well as identified the proteins bound to the nanoparticle surface. We show that Au nanoparticles aggregate in pure tap water, but to a lesser extent in water that either contains Daphnia or has been pre-conditioned with Daphnia. Moreover, we show that proteins generated by Daphnia bind to the Au nanoparticles and create a modified surface that renders them less prone to aggregation. We conclude that the surrounding milieu, as well as the surface properties of the original Au particles, are important factors in determining how the nanoparticles are affected by biological metabolism. In a broader context, our results show how nanoparticles released into a natural ecosystem become chemically and physically altered through the dynamic interactions between particles and organisms, either through biological metabolism or through the interactions with biomolecules excreted by organisms into the environment.</p>},
  author       = {Mattsson, Karin and Aguilar, Ruben and Torstensson, Oscar and Perry, Diana and Bernfur, Katja and Linse, Sara and Hansson, Lars Anders and Åkerfeldt, Karin S. and Cedervall, Tommy},
  issn         = {1743-5390},
  keyword      = {aggregation,Daphnia magna,gold,mass spectrometry,nanoparticles,protein corona},
  language     = {eng},
  month        = {09},
  number       = {8},
  pages        = {885--900},
  publisher    = {Informa Healthcare},
  series       = {Nanotoxicology},
  title        = {Disaggregation of gold nanoparticles by Daphnia magna},
  url          = {http://dx.doi.org/10.1080/17435390.2018.1485982},
  volume       = {12},
  year         = {2018},
}