Interplay of α-synuclein with Lipid Membranes : Cooperative Adsorption, Membrane Remodeling and Coaggregation
(2023) In JACS Au- Abstract
α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α-synuclein amyloid fibrils is associated with several neurodegenerative diseases, most notably Parkinson’s Disease. The molecular mechanisms of both the physiological and pathological functions of α-synuclein remain to be fully understood, but in both cases, interactions with membranes play an important role. In this Perspective, we discuss several aspects of α-synuclein interactions with lipid membranes including cooperative adsorption, membrane remodeling and α-synuclein amyloid fibril formation in the presence of lipid membranes. We highlight the... (More)
α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α-synuclein amyloid fibrils is associated with several neurodegenerative diseases, most notably Parkinson’s Disease. The molecular mechanisms of both the physiological and pathological functions of α-synuclein remain to be fully understood, but in both cases, interactions with membranes play an important role. In this Perspective, we discuss several aspects of α-synuclein interactions with lipid membranes including cooperative adsorption, membrane remodeling and α-synuclein amyloid fibril formation in the presence of lipid membranes. We highlight the coupling between the different phenomena and their interplay in the context of physiological and pathological functions of α-synuclein.
(Less)
- author
- Makasewicz, Katarzyna LU ; Linse, Sara LU and Sparr, Emma LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- amyloid formation, cooperative adsorption, cooperativity, lipid membrane remodelling, protein−lipid coaggregation, α-synuclein, lipids
- in
- JACS Au
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85188249922
- ISSN
- 2691-3704
- DOI
- 10.1021/jacsau.3c00579
- language
- English
- LU publication?
- yes
- id
- fd7af632-bc59-4ada-a973-879a301116e3
- date added to LUP
- 2024-04-03 14:57:02
- date last changed
- 2024-04-03 14:58:14
@article{fd7af632-bc59-4ada-a973-879a301116e3,
abstract = {{<p>α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α-synuclein amyloid fibrils is associated with several neurodegenerative diseases, most notably Parkinson’s Disease. The molecular mechanisms of both the physiological and pathological functions of α-synuclein remain to be fully understood, but in both cases, interactions with membranes play an important role. In this Perspective, we discuss several aspects of α-synuclein interactions with lipid membranes including cooperative adsorption, membrane remodeling and α-synuclein amyloid fibril formation in the presence of lipid membranes. We highlight the coupling between the different phenomena and their interplay in the context of physiological and pathological functions of α-synuclein.</p>}},
author = {{Makasewicz, Katarzyna and Linse, Sara and Sparr, Emma}},
issn = {{2691-3704}},
keywords = {{amyloid formation; cooperative adsorption; cooperativity; lipid membrane remodelling; protein−lipid coaggregation; α-synuclein, lipids}},
language = {{eng}},
publisher = {{The American Chemical Society (ACS)}},
series = {{JACS Au}},
title = {{Interplay of α-synuclein with Lipid Membranes : Cooperative Adsorption, Membrane Remodeling and Coaggregation}},
url = {{http://dx.doi.org/10.1021/jacsau.3c00579}},
doi = {{10.1021/jacsau.3c00579}},
year = {{2023}},
}