The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin
(2022) In BMC Endocrine Disorders 22(1).- Abstract
AIMS: Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss.
METHODS: Immigrants from the Middle East at high risk for type 2 diabetes were... (More)
AIMS: Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss.
METHODS: Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months' duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression.
OUTCOMES: Primary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT.
RESULTS: During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041).
CONCLUSION: In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed.
TRIAL REGISTRATION: This study is a secondary analysis of the RCT trial registered at www.CLINICALTRIALS.gov . REGISTRATION NUMBER: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines.
(Less)
- author
- Bennet, Louise LU ; Fawad, Ayesha LU ; Struck, Joachim ; Larsson, Sara Lönn LU ; Bergmann, Andreas and Melander, Olle LU
- organization
-
- EpiHealth: Epidemiology for Health
- EXODIAB: Excellence of Diabetes Research in Sweden
- Family Medicine and Community Medicine (research group)
- Cardiovascular Research - Hypertension (research group)
- Family Medicine and Clinical Epidemiology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2022-10-31
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Diabetes Mellitus, Type 2/complications, Exercise, Life Style, Weight Loss, Obesity/therapy
- in
- BMC Endocrine Disorders
- volume
- 22
- issue
- 1
- article number
- 264
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:36316682
- scopus:85141077343
- ISSN
- 1472-6823
- DOI
- 10.1186/s12902-022-01183-4
- language
- English
- LU publication?
- yes
- id
- fdc4e357-73aa-4e96-9276-7986bbc76234
- date added to LUP
- 2022-12-01 12:22:41
- date last changed
- 2024-05-30 19:57:28
@article{fdc4e357-73aa-4e96-9276-7986bbc76234, abstract = {{<p>AIMS: Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss.</p><p>METHODS: Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months' duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression.</p><p>OUTCOMES: Primary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT.</p><p>RESULTS: During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041).</p><p>CONCLUSION: In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed.</p><p>TRIAL REGISTRATION: This study is a secondary analysis of the RCT trial registered at www.CLINICALTRIALS.gov . REGISTRATION NUMBER: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines.</p>}}, author = {{Bennet, Louise and Fawad, Ayesha and Struck, Joachim and Larsson, Sara Lönn and Bergmann, Andreas and Melander, Olle}}, issn = {{1472-6823}}, keywords = {{Humans; Diabetes Mellitus, Type 2/complications; Exercise; Life Style; Weight Loss; Obesity/therapy}}, language = {{eng}}, month = {{10}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Endocrine Disorders}}, title = {{The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin}}, url = {{http://dx.doi.org/10.1186/s12902-022-01183-4}}, doi = {{10.1186/s12902-022-01183-4}}, volume = {{22}}, year = {{2022}}, }