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Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia

Bergeron, David ; Mattsson, Niklas LU ; Nilsson, Christer LU ; Hansson, Oskar LU ; Ossenkoppele, Rik LU and , (2018) In Annals of Neurology 84(5). p.729-740
Abstract
OBJECTIVE: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401], and mixed/unclassifiable [n = 74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n = 600], PET [n = 366], and/or autopsy [n = 378]) available. The estimated prevalence of amyloid positivity according to PPA variant, age, and apolipoprotein E (ApoE) ε4 status was determined using... (More)
OBJECTIVE: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401], and mixed/unclassifiable [n = 74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n = 600], PET [n = 366], and/or autopsy [n = 378]) available. The estimated prevalence of amyloid positivity according to PPA variant, age, and apolipoprotein E (ApoE) ε4 status was determined using generalized estimating equation models. RESULTS: Amyloid-β positivity was more prevalent in lvPPA (86%) than in nfvPPA (20%) or svPPA (16%; p  (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Neurology
volume
84
issue
5
pages
12 pages
publisher
John Wiley and Sons Inc.
external identifiers
  • scopus:85056802535
ISSN
1531-8249
DOI
10.1002/ana.25333
language
English
LU publication?
yes
id
fdec4fe3-bc37-4bcf-8c66-9fe4a26c81de
date added to LUP
2018-11-27 14:59:36
date last changed
2019-09-17 04:44:30
@article{fdec4fe3-bc37-4bcf-8c66-9fe4a26c81de,
  abstract     = {OBJECTIVE: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401], and mixed/unclassifiable [n = 74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n = 600], PET [n = 366], and/or autopsy [n = 378]) available. The estimated prevalence of amyloid positivity according to PPA variant, age, and apolipoprotein E (ApoE) ε4 status was determined using generalized estimating equation models. RESULTS: Amyloid-β positivity was more prevalent in lvPPA (86%) than in nfvPPA (20%) or svPPA (16%; p },
  author       = {Bergeron, David  and Mattsson, Niklas and Nilsson, Christer and Hansson, Oskar and Ossenkoppele, Rik and , },
  issn         = {1531-8249},
  language     = {eng},
  number       = {5},
  pages        = {729--740},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Annals of Neurology},
  title        = {Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia},
  url          = {http://dx.doi.org/10.1002/ana.25333},
  volume       = {84},
  year         = {2018},
}