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Infective endocarditis caused by HACEK group bacteria—a registry-based comparative study

Bläckberg, Anna LU ; Morenius, Christian ; Olaison, Lars ; Berge, Andreas LU and Rasmussen, Magnus LU (2021) In European Journal of Clinical Microbiology and Infectious Diseases 40(9). p.1919-1924
Abstract

Infective endocarditis (IE) caused by bacteria within Haemophilus (excluding Haemophilus influenzae), Aggregatibacter, Cardiobacterium, Eikenella and Kingella (HACEK) is rare. This study aimed to describe clinical features of IE caused by HACEK genera in comparison with IE due to other pathogens. Cases of IE due to HACEK were identified through the Swedish Registry of Infective Endocarditis (SRIE). Clinical characteristics of IE cases caused by HACEK were compared with cases of IE due to other pathogens reported to the same registry. Ninety-six patients with IE caused by HACEK were identified, and this corresponds to 1.8% of all IE cases. Eighty-three cases were definite endocarditis, and the mortality rate was 2%. The median age was 63... (More)

Infective endocarditis (IE) caused by bacteria within Haemophilus (excluding Haemophilus influenzae), Aggregatibacter, Cardiobacterium, Eikenella and Kingella (HACEK) is rare. This study aimed to describe clinical features of IE caused by HACEK genera in comparison with IE due to other pathogens. Cases of IE due to HACEK were identified through the Swedish Registry of Infective Endocarditis (SRIE). Clinical characteristics of IE cases caused by HACEK were compared with cases of IE due to other pathogens reported to the same registry. Ninety-six patients with IE caused by HACEK were identified, and this corresponds to 1.8% of all IE cases. Eighty-three cases were definite endocarditis, and the mortality rate was 2%. The median age was 63 years, which was lower compared to patients with IE caused by other pathogens (66, 70 and 73 years respectively, p ≤ 0.01). Patients with IE caused by Haemophilus were younger compared to patients with IE due to Aggregatibacter (47 vs 67 years, p ≤ 0.001). Patients with IE due to HACEK exhibited longer duration from onset of symptoms to hospitalization and had more prosthetic valve endocarditis compared to patients with IE due to Staphylococcus aureus (10 vs 2 days, p ≤ 0.001, and 35 vs 14%, p ≤ 0.001). This is, to date, the largest study on IE due to HACEK. Aggregatibacter was the most common cause of IE within the group. The condition has a subacute onset and often strikes in patients with prosthetic valves, and the mortality rate is relatively low.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic therapy, HACEK, Infective endocarditis, Pathogen
in
European Journal of Clinical Microbiology and Infectious Diseases
volume
40
issue
9
pages
1919 - 1924
publisher
Springer
external identifiers
  • pmid:33852103
  • scopus:85104355346
ISSN
0934-9723
DOI
10.1007/s10096-021-04240-3
language
English
LU publication?
yes
id
fe1c30be-f026-4588-9677-3ac2c193ebaa
date added to LUP
2021-04-27 08:56:39
date last changed
2024-06-15 10:33:47
@article{fe1c30be-f026-4588-9677-3ac2c193ebaa,
  abstract     = {{<p>Infective endocarditis (IE) caused by bacteria within Haemophilus (excluding Haemophilus influenzae), Aggregatibacter, Cardiobacterium, Eikenella and Kingella (HACEK) is rare. This study aimed to describe clinical features of IE caused by HACEK genera in comparison with IE due to other pathogens. Cases of IE due to HACEK were identified through the Swedish Registry of Infective Endocarditis (SRIE). Clinical characteristics of IE cases caused by HACEK were compared with cases of IE due to other pathogens reported to the same registry. Ninety-six patients with IE caused by HACEK were identified, and this corresponds to 1.8% of all IE cases. Eighty-three cases were definite endocarditis, and the mortality rate was 2%. The median age was 63 years, which was lower compared to patients with IE caused by other pathogens (66, 70 and 73 years respectively, p ≤ 0.01). Patients with IE caused by Haemophilus were younger compared to patients with IE due to Aggregatibacter (47 vs 67 years, p ≤ 0.001). Patients with IE due to HACEK exhibited longer duration from onset of symptoms to hospitalization and had more prosthetic valve endocarditis compared to patients with IE due to Staphylococcus aureus (10 vs 2 days, p ≤ 0.001, and 35 vs 14%, p ≤ 0.001). This is, to date, the largest study on IE due to HACEK. Aggregatibacter was the most common cause of IE within the group. The condition has a subacute onset and often strikes in patients with prosthetic valves, and the mortality rate is relatively low.</p>}},
  author       = {{Bläckberg, Anna and Morenius, Christian and Olaison, Lars and Berge, Andreas and Rasmussen, Magnus}},
  issn         = {{0934-9723}},
  keywords     = {{Antibiotic therapy; HACEK; Infective endocarditis; Pathogen}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1919--1924}},
  publisher    = {{Springer}},
  series       = {{European Journal of Clinical Microbiology and Infectious Diseases}},
  title        = {{Infective endocarditis caused by HACEK group bacteria—a registry-based comparative study}},
  url          = {{http://dx.doi.org/10.1007/s10096-021-04240-3}},
  doi          = {{10.1007/s10096-021-04240-3}},
  volume       = {{40}},
  year         = {{2021}},
}